Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Reexamination Certificate
2011-01-04
2011-01-04
Weber, Jon P (Department: 1657)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
C424S488000
Reexamination Certificate
active
07862831
ABSTRACT:
The present invention relates to the covalent binding of a hydrogel to an extracellular matrix (ECM). The integration of the hydrogel with the tissue is superior to that in previous techniques. Moreover, unlike previous techniques, the present invention does not require a photoinitiator. Potential therapeutic applications include tissue repair and delivery of drugs or cells. The ECM is first exposed, then treated with a priming agent. Then a polymerizable agent is added and crosslinked to the ECM. Two primary embodiments of methods are disclosed. In the first, the priming agent is an oxidizer which creates tyrosyl radicals in the ECM, which are then bound by acrylate groups in the polymerizable agent. In the second, the priming agent contains aldehydes which bind amino groups in the ECM.
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Elisseeff Jennifer H.
Ratcliffe Anthony
Wang Dong-an
Bose McKinney & Evans LLP
Schuberg Laura
Synthasome, Inc.
Weber Jon P
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