Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Reexamination Certificate
2011-03-01
2011-03-01
Weber, Jon P (Department: 1657)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
C424S488000
Reexamination Certificate
active
07897165
ABSTRACT:
The present invention relates to the covalent binding of a hydrogel to an extracellular matrix (ECM). The integration of the hydrogel with the tissue is superior to that in previous techniques. Moreover, unlike previous techniques, the present invention does not require a photoinitiator. Potential therapeutic applications include tissue repair and delivery of drugs or cells.The ECM is first exposed, then treated with a priming agent. Then a polymerizable agent is added and crosslinked to the ECM.Two primary embodiments of methods are disclosed. In the first, the priming agent is an oxidizer which creates tyrosyl radicals in the ECM, which are then bound by acrylate groups in the polymerizable agent. In the second, the priming agent contains aldehydes which bind amino groups in the ECM.
REFERENCES:
patent: 5017229 (1991-05-01), Burns et al.
patent: 5344459 (1994-09-01), Swartz
patent: 5399665 (1995-03-01), Barrera et al.
patent: 5410016 (1995-04-01), Hubbell et al.
patent: 5567435 (1996-10-01), Hubbell et al.
patent: 5573934 (1996-11-01), Hubbell et al.
patent: 5681353 (1997-10-01), Li et al.
patent: 5700848 (1997-12-01), Soon-Shiong et al.
patent: 5709854 (1998-01-01), Griffith-Cima et al.
patent: 5749968 (1998-05-01), Melanson et al.
patent: 5811094 (1998-09-01), Caplan et al.
patent: 5834274 (1998-11-01), Hubbell et al.
patent: 5837747 (1998-11-01), Soon-Shiong et al.
patent: 5858746 (1999-01-01), Hubbell et al.
patent: 5986043 (1999-11-01), Hubbell et al.
patent: 6060582 (2000-05-01), Hubbell et al.
patent: 6123727 (2000-09-01), Vacanti et al.
patent: 6129761 (2000-10-01), Hubbell
patent: 6132468 (2000-10-01), Mansmann
patent: 6224893 (2001-05-01), Langer et al.
patent: 6258870 (2001-07-01), Hubbell et al.
patent: 6376742 (2002-04-01), Zdrahala et al.
patent: 6410044 (2002-06-01), Chudzik et al.
patent: 6458889 (2002-10-01), Trollsas et al.
patent: 6465001 (2002-10-01), Hubbell et al.
patent: 6468520 (2002-10-01), Rowe et al.
patent: 6471993 (2002-10-01), Shastri et al.
patent: 6554867 (2003-04-01), Joos
patent: 6602294 (2003-08-01), Sittinger et al.
patent: 6602975 (2003-08-01), Hubbell et al.
patent: 6624245 (2003-09-01), Wallace et al.
patent: 6629997 (2003-10-01), Mansmann
patent: 6632246 (2003-10-01), Simon et al.
patent: 6632446 (2003-10-01), Hubbell et al.
patent: 6639014 (2003-10-01), Pathak et al.
patent: 6699471 (2004-03-01), Radice et al.
patent: 6712822 (2004-03-01), Re et al.
patent: 6713085 (2004-03-01), Geistlich et al.
patent: 6723709 (2004-04-01), Pressato et al.
patent: 93/17669 (1993-09-01), None
patent: 94/25080 (1994-11-01), None
patent: WO 02/36147 (2002-05-01), None
Hai et al., Bioconjugate Chem., 2000, vol. 11, pp. 705-713.
Benson, Roberto, Nuclear Instruments and Methods in Physics Research B 191, 2002, pp. 752-757.
Aydelotte, M. et al., “Differences between sub-populations of cultured bovine articular chondrocytes. I: Morphology and cartilage matrix production” Connective Tissue Res., vol. 18, pp. 205-222 (1998).
Aydelotte, M. et al., “Differences between sub-populations of cultured bovine articular chondrocytes. II: Proteoglycan metabolism” Connective Tissue Res., vol. 18, pp. 223-234(1998).
Buckwalter, J. et al., “Articular Cartilage Part I: Tissue Design and chrondrocyte-matrix interactions” The Journal of Bone and Joint Surgery, vol. 79-A, pp. 600-611 (1997).
Buckwalter, J. et al., “Articular Cartilage Part II: Degeneration and osteoarthritis, repair, regeneration, and transplantation” The Journal of Bone and Joint Surgery, vol. 79-A, pp. 612-632 (1997).
Elisseeff, J. et al., “Biological Response of chondrocytes to hydrogels” Ann. N.Y. Acad. Sci. vol. 961, pp. 118-122 (2002).
Elisseeff, J. et al., “Photoencapsulation of chondrocytes in poly(ethylene oxide)-based semi-interpenetrating networks” J. Biomed. Master. res., vol. 51, pp. 164-171 (2000).
Elisseeff, J. et al., “Trasndermal photopolymerization for minimally invasive implatation” Proc. Nat'l. Acad. Sci. USA, vol. 96, pp. 3104-3107(1999).
Healy, K. et al., “Dsigning biomaterials to direct biological responses” Ann. NY Acad. Sci., vol. 875, pp. 24-35 (1999).
Hubbell, J. et al., “Bioactive Biomaterials” Curr. Opin. Biotechnol., vol. 10, pp. 123-129 (1999).
Kim, T.-K, et al., “Experimental Model for Catilage Tissue Engineering to Regernerate the Zonal Organization of Articular Cartilage” OsteoArthritis and Cartilage, vol. 11, pp. 653-664.
Klein, T. et al., “Tissue engineering of stratified articular cartilage from chondrocyte subpopulations” OsteoArthritis and Cartilage, vol. 11, pp. 595-602.
Korver, G. et al., “Compositions of proteoglycans synthesized in different layers of cultured anatomically intact articular cartilage” Matrix, vol. 10, pp. 394-401.
Quinn T. et al., “Controlled enzymatic matrix degradation for integrative cartilage repair” Tissue Engineering, col. 8, pp. 799-806 (2002).
Sawhney, A. et al., “Bioerodibile hydrogels based on photopolymerized poly(ethyleneglycol)-co-poly(alpha-hydroxy acid) diacrylate macromers” Macromolecules, col. 26, pp. 581-587(1993).
Siczkowski, M. et al., “Subpopulations of chondrocytes from different zones of pig articular cartilage” The Journal of Cell Science, vol. 97, pp. 349-360.
Solchaga, L. et al, “Experimental models of cartilage repair: cartilage regeneration using principles of tissue engineering” Clin. Orthopaedics and Related Resolution, vol. 391S, pp. S161-170 (2001).
Temenoff, J. et al., “Review: tissue engineering for regeneration of articular cartilage” Biomaterials, vol. 21, pp. 431-440 (2000).
Waldman, S. et al., “The use of specific choldrocyte populations to modulate the properties of tissue-engineered cartilage” J. Orthopedic Res., col. 14, pp. 424-432.
Wong, M. et al., “Zone-specific cell biosynthetic activity in mature bovine articular cartilage” J. Orthopedic Res., vol. 14, pp. 424-432.
Assam, T. et al., “Cationic polysaccharides for gene delivery” Macromolecules, vol. 35, pp. 9947-9953 (2002).
Y.-R. Chen et al., “An electron spin resonance spin-trapping investigation of the free radicals formed by the reaction of mitochondrial cytochrome c oxidase with H202” J. Biol. Chem., col. 274, pp. 3308-3314 (1999).
S. Qian et al., “Identification of protein-derived tyrosyl radical in the reaction of cytochome c and hydrogen peroxide” Biochem. J., vol. 363, pp. 281-288 (2002).
Q. Li et al., “Heterogeneous-Phase Reaction of Clycidyl Methacrylate and Chondroitin Sulfate: Mechanism of Ring-Opening-Transesterificiation Competition” Macrmolecules, col. 36, pp. 2556-2562 (2003).
Kim, T.-K, et al., “Experimental Model for Catilage Tissue Engineering To Regernerate the Zonal Organization of Articular Cartilage” OsteoArthritis and Cartilage, vol. 11, pp. 653-664, 2003.
Klein, T et al., “Tissue engineering of stratified articular cartilage from chondrocyte subpopulations” OsteoArthritis and Cartilage, vol. 11, pp. 595-602, 2003.
Korver, G. et al., “Compositions of proteoglycans synthesized in different layers of cultured anatomically intact articular cartilage” Matrix, vol. 10, pp. 394-401, 1990.
Siczkowski, M. et al., “Subpopulations of chondrocytes from different zones of pig articular cartilage” The Journal of Cell Science, vol. 97, pp. 349-360, 1990.
Waldman, S. et al., “The use of specific choldrocyte populations to modulate the properties of tissue-engineered cartilage” J. Orthopedic Res., col. 14, pp. 424-432, 2003.
Wong, M. et al., “Zone-specific cell biosynthetic activity in mature bovine articular cartilage” J. Orthopedic Res., vol. 14, pp. 424-432, 1996.
Elisseeff Jennifer
Ratcliffe Anthony
Wang Dong-an
Bose McKinney & Evans LLP
Schuberg Laura
Synthasome, Inc.
Weber Jon P
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