Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1994-02-14
1997-06-17
Arthur, Lisa B.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 912, 536 2433, 935 77, 935 78, C12Q 168, C12P 1934, C07H 2104
Patent
active
056396074
ABSTRACT:
A method is disclosed for detecting a polymorphism in the .delta.-aminolevulinate dehydratase gene which is associated with an altered susceptibility to lead poisoning. A point mutation which generates an MspI restriction endonuclease recognition site was found in the ALAD2 allele of the .delta.-aminolevulinate dehydratase gene which is not present in the ALAD1 allele. Kit containing primers for the amplification of the polymorphic region of the ALAD gene are provided.
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Desnick Robert J.
Wetmur James G.
Arthur Lisa B.
Mount Sinai School of Medicine of the City University of New Yor
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