Method and kits for detecting a polymorphism in .delta.-aminolev

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

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435 912, 536 2433, 935 77, 935 78, C12Q 168, C12P 1934, C07H 2104

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056396074

ABSTRACT:
A method is disclosed for detecting a polymorphism in the .delta.-aminolevulinate dehydratase gene which is associated with an altered susceptibility to lead poisoning. A point mutation which generates an MspI restriction endonuclease recognition site was found in the ALAD2 allele of the .delta.-aminolevulinate dehydratase gene which is not present in the ALAD1 allele. Kit containing primers for the amplification of the polymorphic region of the ALAD gene are provided.

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