Chemistry: analytical and immunological testing – Cancer
Patent
1990-04-12
1993-02-23
Housel, James C.
Chemistry: analytical and immunological testing
Cancer
422 61, 436 63, 436501, 2524081, 435 723, G01N 3348
Patent
active
051889641
ABSTRACT:
The invention relates to a method of predicting disease-free survival in cancer patients by relating the number and amount of stress response proteins in the cancer tissue to the probability of tumor recurrence. Particular heat shock/stress response proteins useful in the determination of tumor recurrence are the stress response proteins, hsp70, hsp90, hsp27, and glucose regulated protein grp94. Specific levels of the stress response proteins are identified, above which the probability of tumor recurrence is highly signficant. Kit methods are disclosed which could enable determination of the stress proteins by an antibody assay.
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Chamness Gary C.
Clark Gary M.
McGuire William L.
Tandon Atul K.
Board of Regents , The University of Texas System
Chan William
Housel James C.
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