Method and kit for the early detection of impaired renal status

Details Method and kit for the early detection of impaired renal status Method and kit for the early detection of impaired renal status

2007-04-19

2010-02-16

Cook, Lisa V (Department: 1641)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C435S007100, C436S501000, C436S518000, C422S067000

Reexamination Certificate

active

07662578

ABSTRACT:
A method and kit for identifying the presence of an early biomarker of impaired renal status following a renal event in a mammalian subject. The method typically comprises (a) providing a body fluid sample obtained from a mammalian subject following a renal event; and (b) detecting in the provided sample the presence of a protein selected from the group consisting of aprotinin, alpha-1-microglobulin (A1M), alpha-1-acid-glycoprotein (A1AG), microalbumin, and combinations thereof, the presence thereof serving as an early biomarker of a change in renal status. The method can include a kit for point-of-care detection of the early biomarker of impaired renal status. Identification of the presence or absence of the early biomarker typically directs a caregiver's therapeutic decision regarding managing treatment of the subject for impaired renal status. The invention also includes a method of assessing the administration of aprotinin during cardiopulmonary bypass surgery and provides for methods where the level of aprotinin in the subject's urine directs a caregiver's therapeutic decision regarding the intra-operative administration of aprotinin.

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Jain, Samta, et al., “Proteomic Analysis of Urinary Protein Markers for Accurate Prediction of Diabetic Kidney Disorder” JAPI, Jun. 2005, vol. 53, pp. 513-520.
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