Chemistry: analytical and immunological testing – Composition for standardization – calibration – simulation,... – Blood serum or blood plasma standard or control
Reexamination Certificate
2007-10-23
2007-10-23
Gabel, Gailene R. (Department: 1641)
Chemistry: analytical and immunological testing
Composition for standardization, calibration, simulation,...
Blood serum or blood plasma standard or control
C435S007100, C435S007940, C436S008000, C436S015000, C436S016000, C436S017000, C436S018000, C436S164000, C436S166000, C436S172000, C436S176000, C436S177000, C436S517000, C530S380000
Reexamination Certificate
active
10187310
ABSTRACT:
The invention provides a method for assaying for troponin I in a sample such as serum, the method comprising a determination of the troponin I concentration in a sample using a standard preparation that comprises a complete native troponin complex. One exemplary assay for troponin I concentration according to the invention is an immunoassay. Further contemplated in the method is a step comprising contacting the sample with a Ca2+-binding agent. Another aspect of the invention is the standard preparation comprising a complete native troponin complex. Yet another aspect of the invention is a kit for use in the assay method comprising the standard preparation, a detectable label, and a troponin I binding partner, such as an anti-troponin I antibody. All aspects of the invention are usefully practiced using human materials, such as a human troponin complex, and/or human sources for samples.
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Bersenikova Anastasia
Esakova Tatiana
Katrukha Alex G.
Pettersson Kim
Severin Sergei
Gabel Gailene R.
Hytest Ltd.
Marshall & Gerstein & Borun LLP
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