Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1997-02-28
1999-06-15
Zitomer, Stephanie
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 912, 435975, 536 231, 536 2431, 536 2433, 935 77, 935 78, C12Q 168, C12P 1934, C07H 2104, C07H 2102
Patent
active
059121270
ABSTRACT:
The association between the presence of one or more rare (infrequent) alleles of the HRAS variable tandem repeat (VTR) polymorphism and the incidence of ovarian cancer in women who harbor a BRCA1 mutation can be used for evaluating risk of ovarian cancer in a human patient. The patient is tested for the presence of a mutation in the BRCA1 gene; and to determine the polymorphic form of the HRAS1 variable tandem repeat region. The presence of both a mutation in the BRCA1 gene and a rare polymorphic form of the HRAS1 variable tandem repeat region is indicative of an elevated risk of developing ovarian cancer. A kit for performing this evaluation includes reagents necessary for performing a test for the BRCA1 mutation and to evaluate the polymorphic form of the HRAS1 variable tandem repeat region.
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Narod Steven A.
Phelan Catherine M.
McGill University
Zitomer Stephanie
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