Method and kit for evaluating human papillomavirus transformed c

Details Method and kit for evaluating human papillomavirus transformed c Method and kit for evaluating human papillomavirus transformed c

1995-03-17

1998-04-07

Knode, Marian C.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

435183, 4242041, 4242771, 530395, C12Q 170, C12N 900, A61K 3912, C07K 100

Patent

active

057363188

ABSTRACT:
The invention provides methods and kits for determining the extent of interaction and/or inactivation between a cyclin/cyclin-dependent kinase inhibitor and the human papilomavirus E7 oncoprotein and thus for evaluating the proliferative state of a transformed cell. Methods for identifying compounds capable of inhibiting the interaction between a cyclin/cyclin-dependent kinase inhibitor and the human papilomavirus E7 oncoprotein, and for inhibiting growth of a human papillomavirus-associated carcinoma cell are also provided.

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Xiong et al. (1993) Nature 366:701-704.
Xiong Y. et al Subunit rearrangement of the cyclon-dependent kinase is associated with cellular transformation. Genes & Development 7:1572-1583 1993.
Vousden, K.A. Human Papillomaviruses & Cervical Cancer. Stern P L et al New York, Ny. 1994 Oxford Univ. Press p. 92.

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