Method and kit for diagnosing bloom's syndrome

Details Method and kit for diagnosing bloom's syndrome Method and kit for diagnosing bloom's syndrome

1987-02-12

1989-04-04

Marantz, Sidney

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 4, 4351722, 43524027, 435810, 436512, 436548, 436811, 935110, G01N 3353, G01N 33535, G01N 33577

Patent

active

048186856

ABSTRACT:
A method and kit for diagnosing Bloom's syndrome are provided relying on specific monoclonal antibodies, such as ATCC HB-9311, which recognize the base excision repair pathway enzyme uracil DNA glycosylase from normal healthy individuals and individuals afflicted with genetic syndromes, but fails to recognize uracil DNA glycosylase from individuals afflicted with Bloom's Syndrome.

REFERENCES:
patent: 4442203 (1984-04-01), Varsharsky
patent: 4699877 (1987-10-01), Cline
Chemical Abstracts, 104:127689c (1986).
Y. Yamamoto et al., "Abnormal Regulation of Uracil-DNA Glycosylase Induct During Cell Cycle and Cell Passage in Bloom's Syndrome Fibroblasts", Carcinogenesis, vol. 7, No. 2, pp. 305-310 (1986).
P. K. Gupta et al., "Altered Temporal Expression of DNA Repair in Hypermutable Bloom's Syndrome Cells", Proc. Natl. Acad. Sci. U.S.A., vol. 81, pp. 757-761, (Feb. 1984).
Arenaz et al., "Isolation and Characterization of Monoclonal Antibodies Directed Against the DNA Repair Enzyme Uracil DNA Glycosylase from Human Placenta", Proc. Natl. Acad. Sci. U.S.A., 80:5822.5826 (1983).

Affiliated with

Also associated with

Rating

Method and kit for diagnosing bloom's syndrome does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method and kit for diagnosing bloom's syndrome, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method and kit for diagnosing bloom's syndrome will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-180159