Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1990-08-09
1992-05-26
Lee, Lester L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 2, 530313, 530328, 930110, 930DIG801, 930DIG802, 930DIG690, 930DIG800, A61K 3738
Patent
active
051168189
ABSTRACT:
A method of providing contraception for and regulation of the menstrual cycle of a gonadal female mammal by a) administering thereto about once a week throughout her menstrual cycle an amount of a GnRH-antagonist effective to block folliculogenesis and thereby achieve a contraceptive state but less than the amount thereof required to block hormonogenesis; and b) inducing menses by administering during the last half of that cycle an amount of a progestin effective to produce a secretory endometrium and then terminating the progestin administration.
REFERENCES:
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Santoro et al., Endocrine Reviews, vol. 7, No. 1, pp. 11-23 (1986).
Kenigsberg et al., Endocrine Reviews, vol. 7, No. 1 pp. 34-43, 1986.
Danforth et al., "Intermittent GnRH Antagonist Plus Progestin Contraception Conserving Tonic Ovarian Estrogen Secretion and Reducing Progestin Exposure", Contraception, Jun. 1990, vol. 41, No. 6, pp. 623-631.
Williams, R. F., and Hodgen, G. D., "The Reproductive Cycle in Female Macaques", American Journal of Primatology Supplement, 1:181-192 (1982).
Goodman, A. L., and Hodgen, G. D., "The Ovarian Triad of the Primate Menstrual Cycle", Recent Progress in Hormone Research, vol. 39:1-73.
Dizerega, G. S. and Hodgen, G. D., "Folliculogenesis in the Primate Ovarian Cycle", Endocrine Reviews, vol. 2, No. 1:27-49.
Henderson et al., "Re-evaluating the role of progestogen therapy after the menopause", Fertility and Sterility, vol. 49 (Suppl.), No. 5 May 1988.
GnRH Analog Design, Karten et al., vol. 7, No. 1, Feb. 1986 pp. 44-66.
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Gregory Pincus, Control of Fertility in Mammals by Hormonal Steroids, vol. 157, pp. 53-62.
Hodgen Gary D.
Kenigsberg Daniel
Lee Lester L.
Medical College of Hampton Roads
Wessendorf T. D.
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