Method and intermediates for producing .alpha.-L-aspartyl-L-phen

Details Method and intermediates for producing .alpha.-L-aspartyl-L-phen Method and intermediates for producing .alpha.-L-aspartyl-L-phen

1984-02-16

1984-10-30

Phillips, Delbert R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

562571, 549477, C07C10120, C07D30760

Patent

active

044801122

ABSTRACT:
This invention encompasses a method and intermediates for preparing a commercial sweetening agent, .alpha.-L-aspartyl-L-phenylalanine methyl ester. The process involves reacting L-aspartic acid with diketene to form N-acetoacetyl-L-aspartic acid which is converted to N-acetoacetyl-L-aspartic anhydride by reaction with acetic anhydride. N-acetoacetyl-L-aspartic anhydride is reacted with L-phenylalanine methyl ester to provide N-acetoacetyl-.alpha.-L-aspartyl-L-phenylalanine methyl ester which is converted to .alpha.-L-aspartyl-L-phenylalanine methyl ester by reaction with hydroxylamine hydrochloride.

REFERENCES:
patent: 2200220 (1940-05-01), Reppe et al.
patent: 3462460 (1969-08-01), Kollonitsch
patent: 3933781 (1976-01-01), Bachman et al.
patent: 4173562 (1979-11-01), Bachman et al.
Chemical Abstracts, 64, (1966), Abst. No. 19754c.
Carlo Di Bello et al., J. Chem. Soc., (C), 350, (1969).

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