Method and intermediates for producing .alpha.-L-aspartyl-L-phen

Details Method and intermediates for producing .alpha.-L-aspartyl-L-phen Method and intermediates for producing .alpha.-L-aspartyl-L-phen

1984-05-15

1985-11-26

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07C10352

Patent

active

045553629

ABSTRACT:
This invention encompasses a method and intermediates for preparing a commercial sweetening agent, .alpha.-L-aspartyl-L-phenylalanine methyl ester. The process involves reacting L-aspartic acid with diketene to form N-acetoacetyl-L-aspartic acid which is converted to N-acetoacetyl-L-aspartic anhydride by reaction with acetic anhydride. N-acetoacetyl-L-aspartic anhydride is reacted with L-phenylalanine methyl ester to provide N-acetoacetyl-.alpha.-L-aspartyl-L-phenylalanine methyl ester which is converted to .alpha.-L-aspartyl-L-phenylalanine methyl ester by reaction with hydroxylamine hydrochloride.

REFERENCES:
patent: 3879372 (1975-04-01), Boesten
patent: 4440667 (1984-04-01), Dryden et al.
patent: 4480112 (1984-10-01), Dryden et al.
Chemical Abstracts, vol. 64, 1966, Abst. No. 19754C.

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