Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1982-10-29
1986-05-27
Meyers, Albert T.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
A61K 3113
Patent
active
045916055
ABSTRACT:
A method for inhibiting the secretion of stomach acid in vertebrate animals. The method comprises contacting the lumen side of the stomach with a compound which interferes with the acid secretion mechanism yet cannot permeate the lining of the stomach. The compound has a molecular weight of less than 1,200 and at least ten percent of the molecular weight of the compound is due to the molecular weight contribution of secondary amine nitrogen. The invention also includes an ingestible product for inhibiting the secretion of stomach acid in vertebrate animals. The product is ingested so that it is contacted with the lumen side of the stomach to interfere with the acid secretion mechanism without permeating the lining of the stomach. The product contains a compound which has a molecular weight of less than 1200, at least ten percent of the molecular weight of the compound being due to the molecular weight contribution of secondary amine nitrogen. The product is in the form of a solution, dispersion, capsule or tablet.
REFERENCES:
Goodman et al., The Pharmacological Basis of Therapeutics, p. 1001 1965.
Melamed et al., GI Pharm. of Polyethyleneimine, J. Pharm. Sci., 66: 899-901 1977.
Belair et al., Effects of Spermine and Spermidine on Gastric Emptying in Rats, J. Pharm. Sci.: 70: 347, 1981.
Ray et al., Polyamines are Inhibitors of Gastric Secretion PNAS 79: 1448-1452 1982.
Remington's Practice of Pharmacy, pp. 450-452 1948.
McGuire Charles S.
Meyers Albert T.
Research Foundation of State University of New York
Rollins Jr. John W.
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