Method and index for diagnosing insulin resistance

Details Method and index for diagnosing insulin resistance Method and index for diagnosing insulin resistance

2008-01-29

2008-01-29

Weber, Jon (Department: 1657)

Chemistry: molecular biology and microbiology

Maintaining blood or sperm in a physiologically active state...

C436S063000

Reexamination Certificate

active

11240221

ABSTRACT:
The invention provides a method for the determination of insulin sensitivity, insulin resistance, and non-insulin dependent Diabetes mellitus based on oral glucose tolerance test data and lipid ratios from reference populations that define an insulin resistance index. The invention also provides methods for using the IR index to determine disease progression and to evaluate the efficacy of the therapeutic agents. The invention further provides an IR calculator for automating diagnosis, producing and storing patient medical records.

REFERENCES:
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Zavaroni et al. Plasma Nitric Oxide Concentrations are Elevated in Insulin-Resistant Healthy Subjects; Metabolism, vol. 49, No. 8 (2000) pp. 959-961.
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Nyholm B et al. (2004) Evidence of increased visceral obesity and reduced physical fitness in healthy insulin-resistant first-degree relatives . . . Eur J Endocrinol 150:207-214.
Reaven GM et al. 2004. Obesity, Insulin Resistance, and Cardiovascular Disease Recent Prog Horm Res. 59:207-23 (abstract only).

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