Method and index for diagnosing insulin resistance

Chemistry: molecular biology and microbiology – Maintaining blood or sperm in a physiologically active state...

Reexamination Certificate

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C436S063000

Reexamination Certificate

active

07323296

ABSTRACT:
The invention provides a method for the determination of insulin sensitivity, insulin resistance, and non-insulin dependent Diabetes mellitus based on oral glucose tolerance test data and lipid ratios from reference populations that define an insulin resistance index. The invention also provides methods for using the IR index to determine disease progression and to evaluate the efficacy of the therapeutic agents. The invention further provides an IR calculator for automating diagnosis, producing and storing patient medical records.

REFERENCES:
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Zavaroni et al. Plasma Nitric Oxide Concentrations are Elevated in Insulin-Resistant Healthy Subjects; Metabolism, vol. 49, No. 8 (2000) pp. 959-961.
Abbasi F et al. (2002) Relationship between obesity, inuslin resistance, and coronary heart disease risk. J Amer College Cardiol 40:937-43.
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ADA (2003) Economic costs of diabetes in the US in 2002. Diabetes Care 26:917-32.
Facchini F et al. (2001) Insulin resistance as a predictor of age-related diseases. J Clin Endocrin Metabol 86:3574-78.
Hrebicek J et al. (2002) Detection of insulin resistance by simple quantitative insulin check index . . . J Clin Endocrinol Met 87:144-47.
McLaughlin T et al. (2003) Use of Metabolic Markers To Identify Overweight Individuals Who Are Insulin Resistant Ann Intern Med. 139:802-9.
Matsuda M and RA DeFronzo (1999) Insulin Sensitivity Indices Obtained from Oral Glucose Tolerance Testing. Diabetes Care 22:1462-70.
Matthews DR et al.(1985) Homeostasis model assessment: insulin resistance and beta-cell function . . . Diabetologia 28:412-9 (abstract only).
Nyholm B et al. (2004) Evidence of increased visceral obesity and reduced physical fitness in healthy insulin-resistant first-degree relatives . . . Eur J Endocrinol 150:207-214.
Reaven GM et al. 2004. Obesity, Insulin Resistance, and Cardiovascular Disease Recent Prog Horm Res. 59:207-23 (abstract only).

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