Method and formulation for increasing the bioavailability of poo

Details Method and formulation for increasing the bioavailability of poo Method and formulation for increasing the bioavailability of poo

1997-06-13

1999-11-30

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424455, 424498, 514937, A61K 910

Patent

active

059938587

ABSTRACT:
A self-microemulsifying excipient formulation for increasing the bioavailability of a drug which includes an emulsion including an oil or other lipid material, a surfactant, and a hydrophilic co-surfactant. A method for making a drug delivery system for increasing the bioavailability of a drug by emulsifying at least one drug with a self-microemulsifying excipient comprising an oil or other lipid material, a surfactant, and a hydrophilic co-surfactant and drugs formulated thereby.

REFERENCES:
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Farah, N., Laforet, J.P., Denis, J., Self Micro Emulsifying Drug Delivery Systems (SMEDDS) For Improving Dissolution of Drugs: In Vitro, In Vivo Evaluations, 1994 AAPS Annual Meeting--San Diego 1994, Gattefosse Patented Technology.
Bird et al., (1960) in Transport Phenomena, John Wiley & Sons, New York, Chapters 16 and 21.
Farah et al. (1993) Self-microemulsifying drug delivery systems for improving in-vitro dissolution of drugs. AAPS Annual Meeting, Orlando, Florida.
Grundy et al., (1994) Sensitive high-performance liquid chromatographic assay for nifedipine in human plasma . . . J. Chrom. B. Biomedical Applications, 654:146.
Hernell et al., (1990) Physical-chemical behavior of dietary and biliary lipids during intestinal digestion . . . Biochemistry, 29:2041-2056.
Remington's Pharmaceutical Sciences (1975) Hoover, J.E. editor, 15th ed., Mack Publishing Co., Easton, PA, pp. 334-339.
Ritschel (1980) Gastrointestinal absorption of peptides using microemulsions as delivery systems. Gattefosse, No. 83, pp. 7-21.
Sarciaux et al., (1995) Using microemulsion formulations for oral drug delivery of therapeutic peptides. Int'l. Journal of Pharmaceutics, 120:127-136.
Staggers et al., (1990) Physical-chemical behavior of dietary and biliary lipids during intestinal digestion and absorption . . . Biochemistry, 29:2028-2040.

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