Radiant energy – Luminophor irradiation – With ultraviolet source
Reissue Patent
2007-06-05
2007-06-05
Gabor, Otilia (Department: 2884)
Radiant energy
Luminophor irradiation
With ultraviolet source
C250S458100, C600S321000, C600S320000, C600S323000, C356S342000
Reissue Patent
active
10056335
ABSTRACT:
The Laser Induced Fluorescence Attenuation Spectroscopy (LIFAS) method and apparatus preferably include a source adapted to emit radiation that is directed at a sample volume in a sample to produce return light from the sample, such return light including modulated return light resulting from modulation by the sample, a first sensor, displaced by a first distance from the sample volume for monitoring the return light and generating a first signal indicative of the intensity of return light, a second sensor, displaced by a second distance from the sample volume, for monitoring the return light and generating a second signal indicative of the intensity of return light, and a processor associated with the first sensor and the second sensor and adapted to process the first and second signals so as to determine the modulation of the sample. The methods and devices of the inventions are particularly well-suited for determining the wavelength-dependent attenuation of a sample and using the attenuation to restore the intrinsic laser induced fluorescence of the sample. In turn, the attenuation and intrinsic laser induced fluorescence can be used to determined a characteristic of interest, such as the ischemic or hypoxic condition of biological tissue.
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Grundfest Warren S.
Marmarelis Vasilis Z.
Shehada Ramez E. N.
Cedars-Sinai Medical Center
Gabor Otilia
Knobbe Martens Olsen & Bear LLP
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