Measuring and testing – Gas analysis – With compensation detail
Patent
1997-09-23
1999-10-19
Houtteman, Scott W.
Measuring and testing
Gas analysis
With compensation detail
B01D 1508
Patent
active
059692286
ABSTRACT:
Method and devices for performing chromatographic pattern analysis determine chromatographic variability due to a plurality of sources without requiring identification or characterization of peaks or other chromatographic features, receives data indicative of a standard chromatogram and a first sample chromatogram generated from a first mixture by a High Pressure Liquid Chromatography (HPLC) device and data indicative of a plurality of additional sample chromatograms generated by the HPLC device from a plurality of different mixtures. The method and devices generate from the standard chromatogram, a plurality of sets of chromatographic variability data, each set being indicative of a different effect of the chromatographic variability of the HPLC. The standard chromatogram is modified as a function of the variability data, and a residual value, indicative of a difference between the modified standard chromatograms and the first sample chromatogram is generated. Residual values are generated for the additional sample chromatograms and are used to determine differences between the corresponding mixtures and the first mixture.
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Houtteman Scott W.
Janiuk Anthony J.
Michaelis Brian L.
Waters Investments Limited
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