Surgery – Instruments – Electrical application
Reexamination Certificate
2006-09-05
2011-11-15
Cohen, Lee (Department: 3739)
Surgery
Instruments
Electrical application
Reexamination Certificate
active
08057466
ABSTRACT:
A method and device are described to form a sensor using a cardiomyocyte by advancing a catheter into the tissue of interest, cardiac in the preferred embodiment, and using the catheter to ablate a cone- or a dome-shaped region to form an electrically isolated section of tissue. An electrode is later fixed to the region encompassed by the dome-shaped area of tissue and used to detect the electrophysiological activity of this electrically independent cluster of cells. These cells combined with the electrode and a detection circuitry will form a cell-based sensor to monitor the effects of the anti-arrhythmic drugs in the circulation. The inventive device includes an ablation catheter and a sensing lead. Catheter is a hollow conductor which used to carry RF power from the external generator to the myocardium and to form a cone-shaped ablation zone to electrically isolate a part of myocardium from the rest. Sensing lead is a conductor that carries electrical signals from the isolated myocardium back to the implanted monitoring device. Implantable device is the main unit for processing the signals coming back from the sensing lead.
REFERENCES:
patent: 5403306 (1995-04-01), Edwards et al.
patent: 5586981 (1996-12-01), Hu
patent: 6254600 (2001-07-01), Willink et al.
patent: 6432067 (2002-08-01), Martin et al.
patent: 6626855 (2003-09-01), Weng et al.
patent: 7344533 (2008-03-01), Pearson et al.
Christini, et al., Direct biologically based biosensing of dynamic physiological function, American Journal Physiological Heart Circ. Physiol 280: H2006-H2010, 2001.
Haruyama et al., A biosensing system based on extracellular potential recording of ligand-gated ion channel function overexpressed in insect cells, Analytical Chemistry, 75(4), 2003.
Miake, et al., Biological pacemaker created by gene transfer, Nature Publishing Group; 419:132-133, 2002.
Qu, et al., Expression and Function of a Biologcal Pacemaker in Canine Heart, Circulation, 107:1106-1109, 2003.
Subrahmanyam et al., Application of natural receptors in sensors and assays, Analytical Chemistry, 74(16):3942-3951, 2002.
Tang, et al., Genetically engineered biologically based hemostatic bioassay, Annals of Biomedical Engineering, 31:159-162, 2003.
Cohen Lee
Medtronic Inc.
Soldner Michael C.
LandOfFree
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