Liquid purification or separation – Processes – Chromatography
Patent
1996-04-17
1999-01-26
Therkorn, Ernest G.
Liquid purification or separation
Processes
Chromatography
210658, 549510, B01D 1508
Patent
active
058634371
DESCRIPTION:
BRIEF SUMMARY
The present invention is directed to a method for the separation of a mixture containing at least two components and being characterized by the generic part of patent claim 1, as well as a device for the realization of the method.
In order to separate mixtures containing at least two components, it is known that the mixture to be separated is added to a separation phase usually also named stationary phase and that thereafter the phase charged with the mixture is eluted with at least one fluid. If the components to be separated are such components that can be converted into the gas phase without being decomposed, then the above described known separation takes place in a gas-chromatographical way which means that both the mixture to be separated as well as the fluid used for the elution are gases. According to the column-chromatographical separation which is particularly suitable for the separation of such mixtures with components that cannot be converted into the gas phase without being decomposed or chemically modified, the separation phase (stationary phase) arranged in a column is eluted with a liquid or a liquid mixture after the mixture was added. This method can not only be applied to the separation of mixtures for analytical purposes, but also in a industrial scale for the preparative isolation of correspondingly separated components. Furthermore the column-chromatographical method can be applied to the purification of substances.
The disadvantage of the above described preparative column-chromatographical procedure is that it makes it impossible to obtain continuously a separation and isolation of special components out of the mixture. The column-chromatographical preparative procedure rather allows only a discontinuous, batchwise operation, which means that firstly the separation phase charged with the mixture to be separated has to be eluted completely with the fluid and if necessary regenerated, in order to charge it thereafter again with the mixture to be separated. Such a batchwise procedure however is relatively expensive.
The aim of the present invention is to provide a method of the above mentioned kind that allows a continuous separation of a mixture containing at least two components.
This aim is realized according to the invention by a method with the characteristics of patent claim 1.
According to the inventive method for the separation of a mixture containing at least two components, the mixture to be separated is added to a separation phase and thereafter the separation phase charged with the mixture to be separated is eluted with at least one fluid, as it is described initially in the prior art. The inventive method differs from the known method in which the separation phase is arranged stationarily in a column, in the way that according to the inventive method the separation phase is transported from a first station (chamber) where the separation phase is charged with the mixture to be separated, to at least one second station (chamber) where the separation phase is eluted with at least one fluid. In other words, according to the inventive method first of all the mixture to be separated is added to the separation phase and thereafter the separation phase is located separately from the station where the mixture to be separated is added, and is transported to at least one station where then the correspondingly charged separation phase is eluted with at least one fluid.
The inventive method shows a number of advantages. First of all one essential advantage is that the inventive method allows a continuous procedure for the separation of the mixture, preferably also for the separation of a multicomponent-mixture. The inventive method is particularly advantageous when it is used for the isolation of larger amounts of single components found in the mixture to be separated. This does not only lead to an essential increase of the mass expulsion of the single components found in the mixture, but it causes at the same time a clear increase of production, whereby it is not necessary to install
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Jendrny Heinz
Ulbrich Bernhard
Rhone-Poulenc Rorer GmbH
Therkorn Ernest G.
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