Method and device for producing lipid vesicles

Details Method and device for producing lipid vesicles Method and device for producing lipid vesicles

2005-01-18

2005-01-18

Acquah, Samuel A. (Department: 1711)

Plastic and nonmetallic article shaping or treating: processes

Encapsulating normally liquid material

Liquid encapsulation utilizing an emulsion or dispersion to...

C264S004330, C425S005000, C425S007000, C428S402200

Reexamination Certificate

active

06843942

ABSTRACT:
The invention relates to a device for producing lipid vesicles, which is equipped with a line (1) for transporting a polar liquid phase, with a line (2) for transporting an organic liquid phase containing lipids, with a collecting receptacle (7) for accommodating produced lipid vesicles, and with means for conveying the liquid phases through lines (1) and (2). At at least one location, the outer side of line (1) forms a common contact surface with line (2) inside of which a common opening (3) is provided that permits the flow of liquid and joins the inside of line (2) to the inside of line (1). Lines (1) and (2) do not contain agitating or dispersing aids in the area of the opening (3). The invention also relates to a method for the careful production of lipid vesicles, wherein the lipid phase is sprayed under pressure perpendicular to the direction of flow of the polar phase and into the same, whereupon lipid vesicles having a narrow size distribution form spontaneously and without the action of mechanical agitating or dispersing aids.

REFERENCES:
patent: 4206197 (1980-06-01), Goldberg
patent: 4895452 (1990-01-01), Yiournas et al.
patent: 5000887 (1991-03-01), Tenzel et al.
patent: 5834016 (1998-11-01), Naeff et al.
patent: 0 253 619 (1988-01-01), None
patent: WO 0029103 (2000-05-01), None
Batzri, S., et al., “Single Bilayer Liposomes prepared without sonication”,Biochimica et Biophysica Acta, 298 (1973) 1015-1019.
Kremer, J.M.H., et al., “Vesicle of Variable Diameter Prepared by a Modified Injection Method”,Biochemistry, vol. 16, No. 17, 1977, 3932-3935.
Kriftner, R., “Liposome production: the ethanol injection technique and the development of the first approved liposome dermatic”,Liposome Production: The Ethanol Injection Technique, 91-100.
Naeff, R., “Feasibility of topical liposome drugs produced on an industrial scale”,Advanced Drug Delivery Reviews, 18 (1996) 343-347.

Affiliated with

Also associated with

Rating

Method and device for producing lipid vesicles does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method and device for producing lipid vesicles, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method and device for producing lipid vesicles will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3416995