Combinatorial chemistry technology: method – library – apparatus – Method of creating a library – Solid-phase synthesis or particular method of cleavage from...
Reexamination Certificate
1999-08-27
2010-06-15
Low, Christopher (Department: 1639)
Combinatorial chemistry technology: method, library, apparatus
Method of creating a library
Solid-phase synthesis or particular method of cleavage from...
C536S025310, C536S025300, C435S006120
Reexamination Certificate
active
07737088
ABSTRACT:
The present invention relates to arrays of biochemical and/or biofunctional elements such as nucleic acids (oligonucleotides, for example) or other biomolecules on a carrier surface and methods of producing such arrays using photoactivation of predetermined areas for synthesis using an illumination matrix that is computer-controlled to generate an exposure pattern. This exposure pattern can be adjusted and monitored by computer using a light sensor matrix, for example a CCD matrix, to allow precise, controlled illumination of specific regions and therefore attachment of array building blocks to those specific regions. The methods and compositions of the invention permit spatially resolved photochemical synthesis of polymer probes on a carrier.
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Lindner Hans
Müller Manfred
Stähler Cord F.
Stähler Fritz
Stähler Peer F.
Febit Holding GmbH
Gross Christopher M
Low Christopher
Rothwell Figg Ernst & Manbeck P.C.
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