Method and device for mass transfer operation in immunoassays an

Details Method and device for mass transfer operation in immunoassays an Method and device for mass transfer operation in immunoassays an

1980-12-04

1984-06-12

Nucker, Christine M.

Chemistry: analytical and immunological testing

Thyroid hormone tests

436510, 436542, 436800, 436801, 436804, 436808, 436810, 436811, 436816, 436817, 435 7, 422 59, 422 61, 422 68, G01N 3358, G01N 3500, B65D 7100

Patent

active

044542313

ABSTRACT:
The present invention relates to a new technique and device for mass transfer of one or more components from one liquid phase to another liquid phase, involving a physical separation of said two phases.
According to the new technique, the mass transfer and physical separation are carried out in the same device. The device consists of a mixing-reservoir into which is fitted snugly a mixer-separator, having a channel in the vertical axis of the mixer-separator. The two substantially immiscible liquid solutions are introduced into the mixing reservoir, the phases are thoroughly mixed, by moving the mixer-separator in and out the mixing reservoir. After the spontaneous separation into an upper and lower phase, the upper phase is removed by pushing in the mixer-separator said upper phase being accumulated in a collecting container.
The new technique and device can be successfully utilized in the general field of liquid-liquid extraction and particularly applied in immunoassays, where the two basic operations of mass transfer and physical separation of fractions are required.

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patent: 3449081 (1969-06-01), Hughes
patent: 3992150 (1976-11-01), Retzer
patent: 4021352 (1977-05-01), Sarstedt
patent: 4071319 (1978-01-01), Nugent
patent: 4087248 (1978-05-01), Miles
patent: 4197287 (1980-04-01), Piasio et al.
patent: 4254082 (1981-03-01), Schick et al.

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