Combinatorial chemistry technology: method – library – apparatus – Method of creating a library
Reexamination Certificate
2001-03-28
2008-10-07
Schultz, J D (Department: 1639)
Combinatorial chemistry technology: method, library, apparatus
Method of creating a library
C435S006120, C435S068100, C536S025300
Reexamination Certificate
active
07431685
ABSTRACT:
The aim of the invention is to investigate the bonding of substances to target molecules. This is achieved by means of a densely packed device wherein various target molecules are bonded in a large number of sample areas. Cross-contamination and evaporation need to be minimized. The active surface of the sample areas have to be maximized. The inventive solution resides in the use of carrier plates, containing densely packed capillary structures and having a very large inner surface despite small outer dimensions. 1000 times more molecules can be bonded than on a flat outer surface of a comparable size. Cross contamination is avoided by the lack of cross links between the capillaries. Evaporation is minimized by a small outer surface. After the inner surface of the capillaries has been silanized, peptides and peptidomimetics are synthesized in a locally targeted manner. The molecular interactions of components of the substance library with active substances in a solution or a suspension are investigated by means of a local resolution optical detection method. Handling, especially cleaning and covering with substances, is carried out in a simple manner by rinsing liquids through the capillary plate.
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Frey Andreas
Helfman Juergen
Mueller Gerhard
Schmidt Marcus Alexander
Cunniff John J.
Hahn Loeser & Parks LLP
Laser- und Medizin Technologie GmbH
Lundgren Jeffrey S.
Schultz J D
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