Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of...
Reexamination Certificate
2008-05-06
2008-05-06
Rao, Manjunath (Department: 1647)
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
C435S377000, C435S440000, C435S455000
Reexamination Certificate
active
10501525
ABSTRACT:
The invention concerns a method for identifying compounds capable of modulating adipocyte differentiation, which consists in contacting a compound to be tested with genetically modified pre-adipocyte cells overexpressing the REV-ERB ALPHA receptor and measuring the adipocyte differentiation of said genetically modified cells as compared with the adipocyte differentiation of same said genetically modified pre-adipocyte cells in the absence of said compound to be tested.The invention also concerns genetically modified pre-adipocyte cells overexpressing the REV-ERB ALPHA receptor as well as the method for preparing said cells.
REFERENCES:
patent: WO 99/67637 (1999-12-01), None
patent: WO 02/058532 (2002-08-01), None
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Chawla et al, “Peroxisome proliferator and retinoid signaling pathways co-regulate preadipocyte phenotype and survival”, Proceedings of the National Academy of Sciences, vol. 91, No. 5, Mar. 1, 1994, pp. 1786-1790.
Gervois et al, “Fibrates Increase Human REV-ERBα Expression in Liver via a Novel Peroxisome Proliferator-Activated Receptor Response Element”, Molecular Endocrinology, vol. 13, Mar. 1999, pp. 400-409.
Fontaine et al, “The Orphan Nuclear Recdeptor Rev-Erbα Is a Peroxisome Proliferator-activated Receptor (PPAR) γ Target Gene and Promotes PPAR γ-induced Adipocyte Differentiation”, The Journal of Biological Chemistry, vol. 278, No. 39, Sep. 26, 2003, pp. 37672-37680.
Gamett Daniel C
Genfit
Nixon & Vanderhye P.C.
Rao Manjunath
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