Method and device for fragment trace data display in DNA base se

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

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382129, 382191, 382294, 345438, 345439, 345442, C12Q 168

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active

058916326

ABSTRACT:
In a DNA base sequencing, a consensus sequence is obtained by linking a plurality of DNA fragments obtained by a DNA sequencer, and a base sequence to be edited is determined in the consensus sequence. Then, a trace corresponding to the determined base sequence to be edited is identified among traces obtained by the DNA sequencer. The identified trace is displayed in correspondence with the base sequence to be edited. At this time, the base sequence to be edited is displayed so that an interval between bases becomes even.

REFERENCES:
Kerlavage, et al., Proceedings of the Twenty-sixth Annual Hawaii International Conference on System Sciences, 1993.
Lipshutz, et al. "DNA Sequence Confidence Estimation", Genomics, vol. 19, pp. 471-424 (1994).
Gleeson, et al. "A Trace Display And Editing Program for Data From Fluroescence Based Sequencing Machines", Nucleic Acids Research, vol. 19, No. 23, pp. 6481-6483 (1991).
T. Wakasugi, "Protein Nucleic Acid Enzyme", No. 11, vol. 39 (Aug. 5, 1994), pp. 1780-1777.
B. Alberts, et al., "Molecule Biology of Cell" (Jun. 10, 1987), pp. 185-190.
J. D. Watson, et al., "Molecule Biology of a Gene" (Sep. 9, 1988), pp. 240-281.
Dear et al. Nucleic Acid Research. vol. 19, No. 14, pp. 3907-3911, Jul. 25, 1991.

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