Method and device for determining protein using carrier matrix i

Details Method and device for determining protein using carrier matrix i Method and device for determining protein using carrier matrix i

1990-01-25

1992-06-23

Hill, Jr., Robert J.

Chemistry: analytical and immunological testing

Peptide, protein or amino acid

422 56, 427 2, 435805, 436 88, 436169, G01N 2178, G01N 3368

Patent

active

051242664

ABSTRACT:
A test device and method of determining the presence and concentration of proteins, including albumin and Bence Jones proteins, in a test sample are disclosed. The test device includes a test pad comprising a new and improved carrier matrix incorporating an indicator reagent composition capable of interacting with proteins to produce a visually or instrumentally detectable and/or measurable response. The new and improved carrier matrix of the test pad comprises a fibrous, bibulous substrate, such as filter paper, homogeneously impregnated with a polymerized urethane-based compound dispersed in a liquid vehicle comprising an aprotic solvent and an alcohol. The resulting non-greening carrier matrix provides improved color resolution and increased sensitivity to proteins in dry phase test strip assays, thereby affording a more accurate and trustworthy protein assay of liquid test samples, such as urine. The non-greening carrier matrix also essentially eliminates indicator reagent composition runover onto adjacent test pads, such as a pH test pad, in test strips used to assay for more than one analyte. Also disclosed is a method of making the device.

REFERENCES:
patent: 3095277 (1963-06-01), Free et al.
patent: 3438737 (1969-04-01), Atkinson et al.
patent: 3485587 (1969-12-01), Keston
patent: 3704781 (1972-11-01), Dahl
patent: 4298644 (1981-11-01), Shimizu et al.

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