Method and device for controlling mammalian reproductive cycle

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A61N 130

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059418443

ABSTRACT:
A method encompasses the substantially continuous electrotransport delivery of luteinizing hormone releasing hormone (LHRH), prologues, analogues, salts or mixtures thereof, preferably at a substantially constant rate, to a female mammal for the purpose of modifying its reproductive cycle. An electrotransport device substantially is suited for the continuous delivery of LHRH prologues, analogues, salts or mixtures thereof over an extended period of time to a mammal. The present technology may be successfully applied to the controlled breeding of mammals, such as thoroughbred race horses.

REFERENCES:
patent: 3860701 (1975-01-01), Short
patent: 4153689 (1979-05-01), Hirai et al.
patent: 4800191 (1989-01-01), Schally et al.
patent: 5013293 (1991-05-01), Sibalis
patent: 5162306 (1992-11-01), Donaldson
patent: 5312325 (1994-05-01), Sibalis
patent: 5372579 (1994-12-01), Sibalis
patent: 5470847 (1995-11-01), Garfield et al.
Ainsworth, et al., "Continuous Infusion of Gonadotrophin-releasing Hormone (GnRH) Advances the Onset of Oestrous Cycles in Thoroughbred Mares on Australian Studfarms", J. Reprod. Fert. Suppl. 44 (1991), 235-240.
Turner, J.E., et al., "The Effect of Various Gonadotrophin-releasing Hormone Regimens on Gonadotrophines, Follicular Growth and Ovulation in Deeply Anoestrous Mares", J. Reprod. Fert. Suppl. 44 (1991), 213-225.
The Horse, J. W. Evans, 2nd Ed., Ch. 11, pp. 351-373, W.H. Freeman & Co. (1990) "Anatomy and Physiology of Reproduction in the Mare".
Freeman, et al., Mare Management: Economics necessitate knowledge of reproductive cycle. Large Animal Veterinarian Jul./Aug. 1992, pp. 6-8.
Becker, et al., "Effects of Gonadotropin-Releasing Hormone Infused in a Pulsatile or Continuous Fashion on Serum Gonadotropin Concentrations and Ovulation in the Mare". J. Anim. Sci 1992 70:1208-1215.
Hyland, et al., "Control of Transitional Anestrus in Mares by Infusion of Gonadotropin in Releasing Hormone". Theriogeneology, Jun. 1988, vol. 29, No. 6, pp. 1383-1391.
Lowis, et al., "The Effect of an Extended Artificial Photoperiod and Gonadotrophin-releasing Hormone Infusions in Inducing Fertile Oestrus in Anoestrous Mares". Australian Veterinary Journal, vol. 68, No. 12, Dec. 1991, pp. 400-402.
Hyland, et al., "Infusion of Gonadotrophin-releasing Hormone (GnRH) Induces Ovulation and Fertile Oestrus in Mares During Seasonal Anoestrus". J. Reprod. Fert. Suppl. 35 (1987), pp. 211-220.
Meinert, et al., "Advancing the Time of Ovulation in the Mare with a Short-term Implant Releasing the GnRH Analogue Deslorelin". Equine Veterinary Journal (1993), 25 (1) pp. 65-68.
McKinnon, et al., "Short Communications: Predictable Ovulation in Mares Treated with an Implant of the GnRH Analogue Deslorelin", Equine Veterinary Journal (1993) 25 (4) pp. 321-323.
Kesler, D.J., et al., "Constant Delivery of GnRH to Infertile or Subfertile Females with Hypothalamic-Pituitary Axes that Release Hormones in Episodic Bursts". Proceed. Intern. Symp. Control. Rel. Bioact. Mater. 14 (1987), Controlled Release Society, Inc.
Lu, M. Fu, et al., "The Effects of Formulation Variable on Iontophoretic Transdermal Delivery of leuprolide to Humans", Drug Development and Industrial Pharmacy, 19(13), pp. 1557-1571 (1993).
Heit, Mark C., et al., "Transdermal lontophoretic Peptide Delivery: In Vitro and In Vivo Studies with Luteinizing Hormone Releasing Hormone". Journal of Pharmaceutical Sciences, vol. 82, No. 3, Mar. 1993 pp. 240-243.
Kumar, Saran, et al., "Effect of Iontophoresis o in Vitro Skin Permeation of an Analogue of Growth Hormone Releasing Factor in the Hairless Guinea Pig Model". Journal of Pharmacutical Sciences, vol. 81, No. 7, Jul. 1992, pp. 635-639.
Kumar, Saran, et al., "In Vivo Transdermal lontophoretic Delivery of Growth Hormone Releasing Factor GRF (1-44) in Hairless Guinea Pigs". Journal of Controlled Release, 18 (1992) 213-220.
Chen, et al., Pharmaceutical Research vol. 9, No. 10, Oct. 1992 (Supplement), BIOTEC 2023, "Ionotophoretic Transdermal Delivery of LHrh: (II) Effect of electrical Parameters".
Kumar, Krishna, et al., Pharmaceutical Research Vo. 9, No. 10, Oct. 1992 (Supplemental) BIOTEC 2024, "Iontophoretic Transdermal Delivery of a Decapeptide".
Merck Index, pp. 859-860 and 711.
Merck Index, pp. 862-863, 583, 669 and 1234.

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