Chemistry: analytical and immunological testing – Including sample preparation – Dilution
Patent
1996-08-12
1999-08-24
Le, Long V.
Chemistry: analytical and immunological testing
Including sample preparation
Dilution
436 54, 436174, 436180, 422 63, 422 65, 422100, 422102, 422104, 141130, 7386401, G01N 118, B67D 500
Patent
active
059424419
DESCRIPTION:
BRIEF SUMMARY
The invention refers to a method for collection of liquid samples as well as a device for carrying out the method according to the invention. More specificially, the invention refers to a method in which a sampling liquid is delivered by means of a pump to a sample container via a tube which is moved by a transport device in succession from one sample container to the next sample container in several rows of sample containers, the tube after the last sample container in a row being moved to the nearest sample container in the next row.
When medicinal samples are taken--as well as in other instances--a person has to go to the patient or to a place for sampling in order to obtain the necessary sample by means of a canula or some other sampling instrument. This procedure has to be repeated each time a sample is taken. If kinetic changes are to be followed the sampling has to take place with some regularity so that concentration changes with time can be determined with any relevance in subsequent analyses.
The most usual way to regularly take medicinal samples is that somebody inserts a canula into the patient and collects a sample of intervals of for with half an hour. The samples are then transported to another place for analysis, e.g. a laboratory. However, when the results from the analysis are not of acute significance the analysis of the samples can wait until all the samples have been taken.
Apparatuses for regular sampling of blood are described. These apparatuses, built around conventional fraction collectors, are big and can not easily be carried. The patient must thus remain in the vicinity of the permanently stationed apparatus. Systems are also described in which the analysis of the sample takes place continuously. In these cases the analysis is usually based on the determination of glucose. Such a system is described in U.S. Pat. No. 4,123,353.
In more expensive systems for blood sampling the results from the analysis are utilized directly, e.g for regulating the dosage of insulin. On the other hand, if the results from the analysis are not to be used until a test series is completed the same information can be obtained if the laboratory analyses all the samples afterwards. Furthermore, if separate samples are collected at a certain sampling several different types of analyses can advantageously be performed on the same sample.
In order to further facilitate a flexible use the apparatus should be designed to be portable. However, a simple portable system for continuous blood sampling or other kinds of sampling does not exist on the market. An essential prerequisite for a portable equipment is that the liquid samples are not spilled. Furthermore, it is desirable if the samples, when necessary, can be handled aseptically.
The purpose of the present invention is to facilitate and simplify the method of regular or continuous sampling above all during blood sampling by using a portable device which gives a low manufacturing cost. The device for collection of liquid samples according to the invention in includes a special fraction collector which is so constructed that the samples are not spoiled even if the device is turned sideways or upside down.
In order to achieve this purpose the invention has obtained the characterizing features of claim 1 and 9.
In order to explain the invention in more detail two embodiments thereof will be described below reference being made to the accompanying drawings in which
FIG. 1 is an overall view of a device according to the invention,
FIG. 2A is a detail view of the device in cross section,
FIG. 2B corresponds to FIG. 2A but shows another cross section which illustrates another point of the course of sampling,
FIG. 3 is a detail view of the device according to FIG. 1, and
FIG. 4 shows another embodiment of a device according to the invention.
In the overall view of FIG. 1 a sample is sucked out at a sampling point 1. The sample can be blood or some other liquid or suspension which is to be analyzed. At the same time as the sample is sucked out it is usually diluted
REFERENCES:
patent: 3450173 (1969-06-01), Maizel, Jr.
patent: 3623515 (1971-11-01), Gilson
patent: 3999949 (1976-12-01), Andersson et al.
patent: 4362698 (1982-12-01), Boosalis et al.
Le Long V.
Stemu AB
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