Method and device for chromatographic purification

Details Method and device for chromatographic purification Method and device for chromatographic purification

2006-04-27

2010-11-23

Menon, Krishnan S (Department: 1797)

Liquid purification or separation

Processes

Chromatography

C210S659000, C210S198200

Reexamination Certificate

active

07837881

ABSTRACT:
A process for continuous purification of a multi-component mixture by means of individual chromatographic columns though which the mixture is fed by means of at least one solvent. The multi-component mixture comprises at least light impurities, an intermediate product, and heavy impurities. The columns are grouped into at least four sections (α, β, γ, δ) and the fourth section contains three sub-sections (δr, δf, δg). The process operates, alternatingly, in a batch-mode position and in an interconnected-mode position. After or within a switch time, the columns are moved in their function in a counter direction to the general direction of flow of the solvent. The combination of batch chromatography with elements of simulated moving bed techniques, or rather, countercurrent-principles, allows for the separation of a true multi-component mixture, even if one of the products is only present in a small amount, comparatively.

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