Surgery – Means for introducing or removing material from body for... – Infrared – visible light – ultraviolet – x-ray or electrical...
Patent
1996-07-29
1998-09-29
Bockelman, Mark
Surgery
Means for introducing or removing material from body for...
Infrared, visible light, ultraviolet, x-ray or electrical...
604 49, 604113, 604114, 607 88, 607 89, 607 98, 607 99, A61N 130
Patent
active
058140085
ABSTRACT:
A method and apparatus for applying beat to a treatment site prior to effecting photodynamic therapy. The perfusion of a drug into abnormal tissue in a tumor (12) is enhanced by heating the treatment site at which the tumor is disposed using a heat source (26) mounted on a fixture (20, 34) separate from a light source (28) on a probe used to effect the photodynamic therapy. Alternatively, the heat source and light source may comprise different types of light emitting diodes (LEDs) arranged in an array on a probe (14) disposed at the treatment site. Also mounted on the fixture is a temperature sensor (30), which produces a signal indicative of the temperature at the treatment site. In response to this signal, a controller (24/36) controls the heat source to prevent vascular damage. In addition to enhancing the perfusion of a photoreactive agent into the treatment site, heating the tissue at the site prior to initiating the PDT greatly enhances the efficacy of this treatment.
REFERENCES:
patent: 4556057 (1985-12-01), Hiruma et al.
patent: 4822335 (1989-04-01), Kawaii et al.
patent: 4932934 (1990-06-01), Dougherty et al.
patent: 4957481 (1990-09-01), Gatenby
patent: 5066291 (1991-11-01), Stewart
patent: 5257970 (1993-11-01), Dougherty
patent: 5405369 (1995-04-01), Selman et al.
patent: 5445608 (1995-08-01), Chen et al.
patent: 5482719 (1996-01-01), Guillet et al.
patent: 5490840 (1996-02-01), Uzgiris et al.
Nah, Byung Sik, M.D. et al., "Vascular Thermal Adaptation in Tumors and Normal Tissue in Rats," Int. J. Radiation Oncology Biol. Phys., vol. 35, No. 1, pp. 95-101, 1996; .COPYRGT. 1996 Elsevier Science Inc.
Schuster, J.M., et al., "Hyperthermic modulation of radiolabelled antibody uptake in a human glioma xenograft and normal tissues," Int. J. Hyperthermia, 1995, vol. 11, No. 1, .COPYRGT. 1995 Taylor & Francis Ltd., pp. 59-72.
Dewhirst, M.W., "Future directions in hyperthermia biology," Int. J. Hyperthermia, 1994, vol. 10, No. 3, .COPYRGT. 1994 Taylor & Francis Ltd., pp. 339-345.
Ma, L.W., et al., "Effects of Light Exposure on the Uptake of Photofrin II in Tumors and Normal Tissues," Int. J. Cancer: 52, 120-123 (1992), .COPYRGT. 1992 Wiley-Liss, Inc., Publication of the International Union Against Cancer, 4pp.
Yatvin, Milton B. et al., "Design of Liposomes for Enhanced Local Release of Drugs by Hypethermia," Science, vol. 202, 22 Dec. 1978, .COPYRGT. 1978 AAAS, 2pp.
Chen James C.
Wiscombe Brent
Anderson Ronald M.
Bockelman Mark
Light Sciences Limited Partnership
LandOfFree
Method and device for applying hyperthermia to enhance drug perf does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method and device for applying hyperthermia to enhance drug perf, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method and device for applying hyperthermia to enhance drug perf will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-682114