Method and cyclic carbonates for nucleotide analogues

Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system

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544244, 544264, 544265, 544267, 544276, 544277, 544309, 544311, 544312, 544314, 544316, 544317, 549229, C07D47334, C07D47316, C07D31736, C07B 4304

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055147984

ABSTRACT:
An improved method for the preparation of acyclic nucleotide analogues comprises first condensing a cyclic carbonate with a purine or pyrimidine base and then reacting the alkylated base with an activated phosphonate. Novel cyclic carbonates are employed to yield the desired phosphonylmethoxyalkyl nucleotide analogues.

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