Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system
Patent
1995-02-13
1996-05-07
Berch, Mark L.
Organic compounds -- part of the class 532-570 series
Organic compounds
Four or more ring nitrogens in the bicyclo ring system
544244, 544264, 544265, 544267, 544276, 544277, 544309, 544311, 544312, 544314, 544316, 544317, 549229, C07D47334, C07D47316, C07D31736, C07B 4304
Patent
active
055147984
ABSTRACT:
An improved method for the preparation of acyclic nucleotide analogues comprises first condensing a cyclic carbonate with a purine or pyrimidine base and then reacting the alkylated base with an activated phosphonate. Novel cyclic carbonates are employed to yield the desired phosphonylmethoxyalkyl nucleotide analogues.
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Bischofberger Norbert W.
Kent Kenneth M.
Berch Mark L.
Gilead Sciences, Inc.
Hensley Max D.
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