Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1998-01-23
2000-09-26
Schwartzman, Robert A.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
536 245, A61K 3170, C07H 2100
Patent
active
061242713
ABSTRACT:
A method and comjugate for treating H. pylori infection in a subject are disclosed. The conjugate is composed of (a) a nuclease-resistant antisense oligomer effective to inhibit H. pylori infection in the subject by base-specific Watson-Crick binding to an H. pylori mRNA transcript, and (b) a transport moiety conjugated to the oligomer. The transport moiety is effective to facilitate uptake of the conjugate from the environment of the stomach into the cytoplasm of H. pylori cells by active transport or by pH-gradient transport across of the cell membrane of H. pylori. The conjugate is administered by oral route, preferably in a swellable polymer bolus designed to release the conjugate in sustained release.
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Brand Randall
Iversen Patrick L.
Summerton James E.
Weller Dwight D.
AVI BioPharma Inc.
Dehlinger Peter J.
Larson Thomas G
Schwartzman Robert A.
The Board of Regents of the University of Nebraska
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