Method and compounds for treating inflammatory bowel disease

Details Method and compounds for treating inflammatory bowel disease Method and compounds for treating inflammatory bowel disease

1981-03-02

1982-01-26

Breitenstein, G. T.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260207, 424226, 424154, C07C10706, A61K 31655, C09B 4514

Patent

active

043128068

ABSTRACT:
The present invention relates to novel compounds and a method for the prophylaxis and treatment of Inflammatory Bowel Disease (IBD) via the administration of an effective amount in a suitable pharmaceutical dosage form of an azobenzene compound of formula I or a pharmacologically acceptable salt, which is reductively cleaved to 5-aminosalicylic acid (5-ASA) by bacteria in the large intestine.

REFERENCES:
patent: 1157169 (1915-10-01), Mettler
patent: 2894984 (1959-07-01), Hauptschein
patent: 3413225 (1968-11-01), Dmuchovsky et al.
patent: 3674844 (1972-07-01), Shen et al.
King, Chemical Absts., 25, 1684(5), 1931.
Farbenind, Chemical Absts., 28, 5680(2), 1934.

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