Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1996-12-23
1998-12-22
Kight, John
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514 48, 514 51, 536 2622, A61K 3170, C07H 19207
Patent
active
058520015
ABSTRACT:
A method of inhibiting ribonucleases is disclosed wherein a nucleotide compound having a diphosphate group contacts a ribonuclease so as to inhibit the ribonuclease from effectively catalyzing the depolymerization of ribonucleic acid. Novel compounds useful in the method are also disclosed.
REFERENCES:
patent: 3321463 (1967-05-01), Moffatt
patent: 3709873 (1973-01-01), Fujimoto
patent: 4721672 (1988-01-01), Vallee et al.
patent: 4897464 (1990-01-01), Vallee et al.
patent: 4900673 (1990-02-01), Harper et al.
patent: 4916073 (1990-04-01), Vallee et al.
patent: 4966849 (1990-10-01), Vallee et al.
patent: 4966964 (1990-10-01), Shapiro et al.
patent: 5266687 (1993-11-01), Shapiro et al.
patent: 5270204 (1993-12-01), Vallee et al.
patent: 5286487 (1994-02-01), Vallee et al.
patent: 5520914 (1996-05-01), Fett et al.
Sambrook, Fritsch & Maniatis, 1989, Molecular Cloning: A Laboratory Manual; pp. 7.3-7.5 Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY. Month of publication data is unavailable.
Beintema, J.J., 1987, Life Chemistry Reports 4:333-389. Month of publication data is unavailable.
Richards, F.M. and Wyckoff, H.W., 1971 Enzymes Bovine Pancreatic Ribonuclease 4:647-806. Month of publication data is unavailable.
Nogues, M.V., Vilanova, M. & Cuchillo, C.M., 1995, Biochimica et Biophysica Acta 1253:16-24. Month of publication data is unavailable.
Eftink, M.R., & Biltonen, R.L., 1987 Hydrolytic Enzymes, 333-376. Month of publication data is unavailable.
Lee, F.S. and Vallee, B.L., 1993, Progress in Nucleic Acid Research and Molecular Biology 44:1-30. Month of publicatoin data is unavailable.
Lindquist, R.N., Lynn Jr., J.L., & Lienhard, G.E. Dec. 26 1973 Journal of the American Chemical Society 95:8762-8768.
Wlodawer, A., Miller, M., & Sjolin, L., 1983, Proc. Natl. Acad. USA 80:3628-3631 (Jun. 1983).
Berger, S.L. & Birkenmeier, C.S. 1979 Biochemistry 18:5143-5149 (Issue No. 23). Month of publication data is unavailable.
Iwahashi, K., Nakamura, K.T., Mitsui, Y., Ohgi, K. & Irie, M. 1981, J. Biochem. 90:1685-1690 (Issue #6). Month of publication data is unavailable.
White, M.D., Bauer, S. & Lapidot, Y. 1977, Nucleic Acid Research 4:3029-3038 (No. 9, Sep. 1977).
Russo, N., Ravi Acharya, K.R., Vallee, B.L., & Shaprio, R. Jan. 1996, Proc. Natl. Acd. Sci USA 93:804-808.
Shapiro, R., Fett, J.W., Strydom, D.J. & Vallee, B.L. Biochemistry 25:7255-7264 (No. 23, 1986). Month of publication data is unavailable.
Irie, M. Watanabe, H., Ohgi, K., Tobe, M. Matsumura, G., Arata, Y., Hirose, T. & Inayama 1984 J. Biochem, 95, 751-759 (Issue No. 3). Month of publication data is unavailable.
Zegers, I., Maes, D., Dao-Thi, M.H., Poortmans, F., Palmer, R. & Wyns, L. 1994, Protein Science 3:2322-2339. Month of publication data is unavailable.
Wodak, S.Y., Liu,.M.Y, Wyckoff, H.W. 1977, J. Mol. Biol. 116:855-875. Month of publication data is unavailable.
Pavloskhy, A.G., Borisova, S.N., Borisov, V.V., Antonov, I.V., Karpeisky, M.Y. Aug. 1978, FEBS Lett. 92:258-262.
Moffatt, J.G. & Khorana, H.G., 1961, J. Am Chem. Soc. 83:663-675 (Feb. 5, 1961).
Chemical Abstract Search, (1996). Month of publication data is unavailable.
Lee et al., "Kinetic Characterization of Two Active Mutants of Placental Ribonuclease Inhibitor That Lack Internal Repeats," Biochemistry, 29(28), 6633-6638 (Jul. 17, 1990).
Russo et al., "A Combined Kinetic and Modeling Study of the Catalytic Center Subsites of Human Angiogenin," Proc. Nat. Acad. Sci. USA, 93(2), 804-808 (Jan. 23, 1996).
Strydom et al., "An Angiogenic Protein from Bovine Serum and Milk--Purification and Primary Structure of Angiogenin-2," European J. Biochem., 247(2), 535-544 (Jul. 1997).
Hu et al., "A Putative Angiogenin Receptor in Angiogenin-Responsive Human Endothelial Cells," Proc. Nat. Acad. Sci. USA, 94(6), 2204-2209 (Mar. 18, 1997).
Witzel et al., "Mechanism and Binding Sites in the Ribonucleose Reaction II. Kinetic Studies on the First Step of the Reaction," Biochem. Biophys. Research Comm., 7(4), 295-299 (1962).
Russo Aniello
Vallee Bert L.
Crane L. Eric
Kight John
The Endowment for Research in Human Biology
LandOfFree
Method and compounds for inhibition of ribonucleases does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method and compounds for inhibition of ribonucleases, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method and compounds for inhibition of ribonucleases will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2047789