Method and compounds for inhibiting lipid biosynthesis of bacter

Details Method and compounds for inhibiting lipid biosynthesis of bacter Method and compounds for inhibiting lipid biosynthesis of bacter

1994-04-28

1997-12-30

Rollins, John W.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

117927, C12N 910, C30B 2958

Patent

active

057029350

ABSTRACT:
Inha enzyme crystals and methods of growing said crystals are presented. Three crystal forms of the Inha enzyme with discrete unit cell parameters were obtained. The crystals of the Inha enzyme are of sufficient size and quality for x-ray crystallographic determination of the three dimensional structure of the Inha enzyme in concert with heavy atom derivatives of said crystals. With the three dimensional structure of the Inha enzyme, compounds which inhibit the biochemical activity of the Inha enzyme may be developed.

REFERENCES:
patent: 4886646 (1989-12-01), Carter et al.
patent: 4919899 (1990-04-01), Herrmann et al.
patent: 4990216 (1991-02-01), Fujita et al.
Banerjee et al. (1994) Science, 263, "inhA, a Gene Encoding a Target for Isoniazid and Ethionamide in Mycobacterium tuberculosis", pp. 227-230.
Dessen et al. (1995) Science, 267, "Crystal Structure and Function of the Isoniazid Target of Mycobacterium tuberculosis", pp. 1638-1641.
McPherson (1976) Meth. Biochem. Anal., 23, "The Growth and Preliminary Investigation of Protein and Nucleic Acid Crystals for X-Ray Diffraction Analysis", pp. 249-345.
Delucas et al. (1987) Trends Biochem. Technol., 5, "New Direction in Protein Crystal Growth", pp. 188-193.
Giege et al. (1989) Trends Biochem. Technol. 7, "Crystallogenesis of Proteins", pp. 277-282.

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