Method and compounds for aica riboside delivery and for lowering

Details Method and compounds for aica riboside delivery and for lowering Method and compounds for aica riboside delivery and for lowering

1994-12-14

1997-08-19

Wilson, J

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 45, 514 46, 514866, A61K 3170

Patent

active

056588895

ABSTRACT:
AICA riboside and prodrugs of AICA riboside are provided which lower blood glucose for the treatment of various pathologic conditions, including hypoglycemia, insulin deficiency, insulin resistance diabetes and Syndrome X. Prodrugs of AICA riboside provide AICA riboside in an orally bioavailable form. The use of adenosine kinase inhibition and ZMP enhancement for lowering blood glucose are also described.

REFERENCES:
patent: 4912092 (1990-03-01), Gruber
patent: 4943629 (1990-07-01), De Vries et al.
patent: 4968790 (1990-11-01), De Vries et al.

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