Method and compositions useful in preventing equine influenza

Details Method and compositions useful in preventing equine influenza Method and compositions useful in preventing equine influenza

1986-07-21

1990-04-24

Teskin, Robin

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

4351723, 435 691, 435 693, 435320, 435200, 435201, 435235, 935 12, 935 14, C12P 2100, C12P 2102, C07H 1512

Patent

active

049202138

ABSTRACT:
Recombinant vaccines for immunizing horses against equine influenza virus (EIV) are disclosed. The DNA sequences encoding the hemagglutinin (HA) and neuraminidase (NA) glycoproteins from the two strains of EIV currently infective in horses are used to construct vaccinia carried vaccines, to design synthetic peptides for primer and booster administration, and to permit recombinant synthesis of HA and/or NA protein based vaccines. These DNA sequences also provide probes useful for preparing similar vaccines from fresh isolates of new strains generated by genetic drift.

REFERENCES:
Biok et al, Virology, vol. 121, pp. 211-229, 1982, "Sequence Variation at the 3'enl of the Neuraminidaze Gene from 39 Influenza Type A Virses".
Racaniello et al, Proc Hutl Acad Sci., vol. 78 (8), pp. 4887-4891, Aug. 1981, "Molecular Cloning of Polio Virus CDNA and Determination of the Complete Nicleotide Sequence of the Viral Germs".
Air et al, Proc Natl Acad Sci, vol. 78, pp. 7639-7643, 1981, "Sequence Relationships Between the Hemaggletion Genes of Twelve Subtypes of Influenza A Virus".
Lonberg et al, Proc Natl Acad Sci, 1983, vol. 80, pp. 3661-3665.
Daniels et al, J Gen Virol, vol. 66, pp. 457-464, Mar. 1985, "Amino Acid Sequences of Haemagglutatinins of Influenza Viruses of the H.sub.3 b Subtype Isolated from Horses".
Rhode et al, Virology, vol. 79(2), pp. 393-404, 1977, "Biochemical Studies on Influenza Viruses Comparative Analysis of Equine 2 Virus and Virus N Genes and Gene Products".
Schotissek et al, Virology, vol. 79, pp. 330-336, 1977, "Correlation between Base Sequence Homology of RNA Segment 4 and Antiogenicity of the Hemagglutinin of Influenza Viruses".
Souihoua et al, Acta Birol., 1958, vol. 2, pp. 52-61.

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