Method and compositions providing enhanced chemiluminescence fro

Compositions – Chemiluminescent

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252582, 435 4, 435 6, 435 19, 435 21, C09K 300, C12Q 168, C12Q 100, C12Q 144

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049591827

ABSTRACT:
A method and compositions including a 1,2-dioxetane and a fluorescent compound is described. In particular, enzymatic triggering of a triggerable 1,2-dioxetane admixed with a surfactant and the fluorescent compound attached to a hydrocarbon to provide a co-surfactant in a micelle or other structure providing close association of these molecules is described. The method and compositions are useful in immunoassays and in DNA probes used for various purposes.

REFERENCES:
Schaap, A. et al. JACS 1982, 104, 3504.
Wilson, T. et al. JACS 1971, 93, 4126.
Shinkai, S. et al Chem Lett. 1981, 1523.
McCapra, F., Chem. Commun., 155 (1968).
Shimomura et al., Photochem. Photobiol., 30, 89 (1979).
K. R. Kopecky et al., Can. J. Chem., 47, 709 (1969).
P. D. Bartlett et al., J. Amer, Chem. Soc., 92, 3223 (1970).
S. Mazur et al., J. Amer, Chem. Soc., 921, 3225 (1970).
A. P. Schaap et al., J. Amer, Chem. Soc., 99, 1270 (1977).
K. A. Zaklika et al., J. Amer, Chem. Soc., 100, 318, 4916 (1978).
K. A. Zaklika et al., Photochem. Photobiol., 30, 35 (1979).
W. Adam et al., Z. Naturforsch., 39b, 679 (1984).
H. Wynberg et al., Bioluminescence and Chemiluminescence, M. A. Deluca & W. D. McElroy (Eds.) Academic Press, N.Y., p. 687 (1981).
J. C. Hummelen, et al., Methods in Enzymology, 133B, 531 (1986).
A. P. Schaap et al., Organic Photochemical Synthesis, II, 49 (1976).
A. P. Schaap et al., J. Amer. Chem. Soc., 97, 3741 (1975).
A. P. Schaap et al., J. Amer. Chem Soc., 101, 4016 (1979).
J. H. Wieringa et al, Tetrahedron Lett., 169 (1972).
N. J. Turro et al., J. Amer. Chem. Soc., 97, 7110 (1975).
McCapra et al., J. Chem. Soc., Chem. Commun., 944 (1977).
W. Adam et al., Chem. Ber., 116, 839 (1983).
G. Geller et al., Tetrahedron Lett., 673 (1983).
P. Lechtken, Chem. Ber., 109, 2862 (1976).
P. D. Bartlett et al., J. Amer. Chem. Soc., 96, 627, 5557 (1974).
A. P. Schaap et al., J. Amer. Chem Soc. 104, 3504 (1982).
A. P. Schaap et al., Tetrahedron Lett., 2943 (1982).
R. S. Handley et al., Tetrahedron Lett., 3183 (1985).
T. Wilson, Int. Rev. Sci.: Chem., Ser. Two, 9, 265 (1976).
T. Wilson et al., J. Amer. Chem. Soc., 95, 4765 (1973).
T. Wilson et al., J. Amer. Chem. Soc., 93, 4126 (1971).
W. Adam in Chemical & Biological Generation of Excited States, W. Adam & Cilento, Eds. Ch. 4, Academic Press, N.Y. (1982).
E. H., Cordes et al., Acc. Chem. Res., 2,329 (1969).
A. P. Schaap, final technical report to the Office of Naval Research, 1987, p. 16.
T. Goto et al., Tetrahedron Lett., 4299 (1969).
F. McCapra, Acc. Chem. Res., 9, 201 (1976).
C. M. Paleos et al., Bioluminescence and Chemiluminescence, Acad. Press, N.Y., 1981, p. 729.
K. D. Gundermann, Ibid., p. 17.
S. Shinkai et al., Chem. Lett., 1523 (1981).
L. J. Kricka et al., Arch. Biochem. Biophys., 217, 674 (1983).
G. H. Thorpe et al., Clin. Chem., 31, 1335 (1985).
G. H. Thorpe et al., Methods in Enzymology, 133, 331 (1986).
L. J. Kricka et al., Pure & Appl. Chem., 59, 651 (1987).
Y. Kubota et al., Bull. Chem. Soc. Jpn., 46, 100 (1973).
N. E. Shore et al., J. Amer. Chem. Soc., 96, 306 (1974).
G. W. Pohl, Z. Naturforsch., 31c, 575 (1976).
H. R. Schroeder et al., Anal. Chem. 50, 1114 (1978).
H. Arakawa et al., Anal. Biochem, 79, 248 (1979).
H. Arakawa et al., Clin. Chem., 31, 430 (1985).
L. J. Kricka and T. J. N. Carter, Clinical and Biochem. Luminescence, L. Kricka & T. Carter (Eds.) Marcel Dekker, Inc., N.Y., 1982, Ch. 8.
L. J. Kricka, Ligand-Binder Assays, Marcel Dekker, Inc. N.Y. 1982 Ch. 7.
F. McCapra et al., in Bioluminescence & Chemiluminescence: Instru. & Appl., vol. I, K. Van Dyke (Ed.) CRC Press, Inc., New York, 1985 Ch. 2.
G. J. R. Barnard, et al, Ibid., Ch. 7.
L. J. Kricka et al., Methods in Enzymology, 133, 404 (1986).
M. Leong et al., Cytochem., 34, 1645 (1986).
R. A. Bunce et al., Analyst, 110, 657 (1985).
J. Matthews et al., Anal. Biochem., 151, 205 (1985).
G. Thorpe et al., Clin. Chem., 30, 806 (1984).
Catalysis in Micellar and Macromolecular Systems, Published by Academic Press, (1975) Chapt. 1, pp. 1-18.
L. A. Donoso et al., Investigative Ophthalmology & Visual Science, 26, 561 (1985).
A. P. Schaap et al., Tetrahedron Lett., 1155 (1987).
A. P. Schaap et al., Tetrahedron Lett., 935 (1987).
A. P. Schaap et al., Tetrahedron Lett., 1159 (1987).
J. E. McMurry et al., J. Amer. Chem. Soc., 105, 1660 (1983).
J. Lee and H. H. Seliger, Photochem. Photobiol., 15, 227 (1972).
P. R. Michael and L. R. Faulkner, Anal. Chem., 48, 1188 (1976).

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