Method and compositions providing enhanced chemiluminescence fro

Details Method and compositions providing enhanced chemiluminescence fro Method and compositions providing enhanced chemiluminescence fro

1988-07-27

1991-04-02

Lee, Mary C.

Compositions

Chemiluminescent

435147, 435148, 436829, 436905, 424450, 252311, 428402, C08F 800, C09K 300, B01J 1300

Patent

active

050045652

ABSTRACT:
A method and compositions including a 1,2-dioxetane and a fluorescent compound is described. In particular, enzymatic triggering of a triggerable 1,2-dioxetane admixed with a surfactant and the fluorescent compound attached to a hydrocarbon to provide a co-surfactant in a micelle or other structure providing close association of these molecules is described. The method and compositions are useful in immunoassays and in DNA probes used for various purposes.

REFERENCES:
patent: 4315998 (1982-02-01), Neckers et al.
Zimmerman, "Photochemcial Rearrangement Without Light . . . ", J. Am. Chem. Soc. 97(12), 3527-8, 1975.
Wong & Wilson, "Products of . . . Trihydroxychalcone", Phytochemistry 1976, vol. 15, pp. 1325-1332.
Wilson & Wong, "Trihydroxychalcone", Phytochemistry 1976, vol. 15, pp. 1333-1341.
Wong, "Photooxygenation of 2',4,4'-Trihydroxychalcone . . . ", Phytochemistry, vol. 26, No. 5, pp. 1544-1545, 1987.
Schaap et al., "Chemical and Enzymatic Triggering . . . ", Tetrahedron Lett. 28(9) 935-8, 1987.
Schaap et al., "Chemical and Enzymatic Triggering . . . ", Tetrahedron Lett. 28(11) 1155-8, 1987.
Schaap et al., "Mechanisms of Photooxygenation . . . ", J. Am. Chem. Soc. 102 (1), 389-91, 1980.
Jefford et al., "Oxygenation of 3-Aryl-2-Hydroxy Acrylic . . . ", J. Am. Chem. Soc., 100(20), 6432-6, 1978.
Richardson et al., "Substituent Effects Upon Efficiency . . . ", J. Org. Chem., 52(14), 3143-50, 1987.
Wong, "Products from Enzymatic Oxidation . . . ", Tetrahedron Lett., 25(25), 2631-4, 1984.
Richardson et al., "Electronic Effects . . . ", J. Am. Chem. Soc. 104(15), 4173-9, 1982.
Richardson et al., "Substituent Effects . . . ", J. Org. Chem. 50(11), 1803-10, 1985.
Zimmerman et al., "Molecular Rearrangements . . . ", J. Am. Chem. Soc. 98 (18), 5574-81, 1976.
The Chemistry of Synthetic Dyes, vol. VII, K. Venkataraman, 1974, 304-305.
Merck Index, 10th Ed., p. 8138.
McCapra, F., Chem. Commun., 155 (1968).
Shimomura et al., Photochem. Photobiol., 30, 89 (1979).
K. R. Kopecky et al., Can. J. Chem., 47, 709 (1969).
P. D. Bartlett et al., J. Amer. Chem. Soc., 92, 3223 (1970).
S. Mazur et al., J. Amer. Chem. Soc., 92, 3225 (1970).
A. P. Schaap et al., J. Amer. Chem. Soc., 99, 1270 (1977).
K. A. Zaklika et al., J. Amer, Chem. Soc., 100, 318 (1978).
K. A. Zaklika et al., J. Amer. Chem. Soc. 100, 4916 (1978).
K. A. Zaklika et al., Photochem. Photobiol., 30, 35 (1979).
A. P. Schaap et al., Organic Photochemical Synthesis, II, 49 (1976).
A. P. Schaap et al., J. Amer. Chem. Soc., 97, 3741 (1975).
A. P. Schaap et al., J. Amer. Chem. Soc., 101, 4016 (1979).
J. H. Wieringa et al., Tetrahedron Lett., 169 (1972).
N. J. Turro et al., J. Amer. Chem. Soc., 97, 7110 (1975).
A. P. Schaap, J. Amer. Chem. Soc., 97, 3741 (1975).
W. Adam et al., Z. Naturforsch., 39b, 679 (1984).
H. Wynberg et al., Bioluminescence and Chemiluminescence, M. A. Deluca & W. D. McElroy (Eds.) Academic Press, N.Y., p. 687 (1981).
J. C. Hummelen et al., Methods in Enzymology, 133B, 531 (1986).
McCapra et al., J. Chem. Soc., Chem. Commun., 944 (1977).
W. Adam et al., Chem. Ber., 116, 839 (1983).
G. Geller et al., Tetrahedron Lett., 673 (1983).
P. Lechtken, Chem. Ber., 109, 2862 (1976).
P. D. Bartlett et al., J. Amer. Chem. Soc., 96, 627 (1974).
A. P. Schaap et al., J. Amer. Chem. Soc., 104, 3504 (1982).
A. P. Schaap et al., Tetrahedron Lett., 2943 (1982).
R. S. handley et al., Tetrahedron Lett., 3183 (1985).
T. Wilson, Int. Rev. Sci.: Chem., Ser. Two, 9, 265 (1976).
T. Wilson et al., J. Amer. Chem. Soc., 95, 4765 (1973).
P. D. Bartlett et al., J. Amer. Chem. Soc., 96, 5557 (1974).
T. Wilson et al., J. Amer. Chem. Soc., 93, 4126 (1971).
W. Adam in Chemical & Biological Generation of Excited States, W. Adam & Cilento, Eds. Ch. 4, Academic Press, N.Y. (1982).
E. H. Cordes et al., Acc. Chem. Res., 2,329 (1969).
A. P. Schaap, Final Technical Report to the Office of Naval Research, 1987, p. 16.
T. Goto et al., Tetrahedron Lett., 4299 (1969).
F. McCapra, Acc. Chem. Res., 9, 201 (1976).
C. M. Paleos et al., Bioluminescence and Chemiluminescence, Acad. Press, N.Y., 1981, p. 729.
K. D. Gundermann, IBID., p. 17.
S. Shinkai et al., Chem. Lett., 1523 (1981).
L. J. Kricka et al., Arch. Biochem. Biophys., 217, 674 (1983).
G. H. Thorpe et al., Clin Chem., 31, 1335 (1985).
G. H. Thorpe et al., Methods in Enzymology, 133, 331 (1986).
L. J. Kricka et al., Pure & Appl. Chem., 59, 651 (1987).
Y. Kubota et al., Bull. Chem. Soc., Jpn., 46, 100 (1973).
N. E. Shore et al., J. Amer. Chem. Soc., 96, 306 (1974).
G. W. Pohl, Z. Naturforsch., 31c, 575 (1976).
H. R. Schroeder et al., Anal. Chem. 50, 1114 (1978).
H. Arakawa et al., Anal. Biochem, 79, 248 (1979).
H. Arakawa et al., Clin. Chem., 31, 430 (1985).
L. J. Kricka and T. J. N. Carter, Clinical and Biochem. Luminescence, L. Kricka & T. Carter (Eds.) Marcel Dekker, Inc., N.Y., 1982, Ch. 8.
L. J. Kricka, Ligand-Binder Assays, Marcel Dekker, Inc. N.Y. 1985, Ch. 7.
F. McCapra et al., in Bioluminescence & Chemiluminescence: Instru & Appl., vol. I, K. Van Dyke (Ed) CRC Press, Inc., New York, 1985, Ch. 2.
G. J. R. Barnard et al., Ibid., Ch. 7 (1985).
L. J. Kricka et al., Methods in Enzymology, 133, 404 (1986).
M. Leong et al., Cytochem., 34, 1645 (1986).
R. A. Bunce et al., Analyst, 110, 657 (1985).
J. Matthews et al., Anal. Biochem., 151, 205 (1985).
G. Thorpe et al., Clin. Chem., 30, 806 (1984).
Catalysis in Micellar and Macromolecular Systems, Published by Aca Press, (1975), Chapt. 1, pp. 1-18.
A. P. Schaap et al., Tetrahedron Lett., 1155, 935, 1159 (1987).
J. E. McMurry et al., J. Amer. Chem. Soc., 105, 1660 (1983).
J. Lee and H. H. Seliger, Photochem. Photobiol., 15, 227 (1972).
P. R. Michael and L. R. Faulkner, Anal. Chem., 48, 1188 (1976).
L. A. Donoso et al., Investigative Ophthalmology & Visual Science, 26, 561 (1985).

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