Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1989-09-26
1991-02-26
Friedman, Stanley J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
A61K 3138
Patent
active
049962264
ABSTRACT:
This invention provides a method for treating the symptoms of parkinsonism which comprises administering to a human or other mammal suffering from the symptoms of parkinsonism an effective amount of a compound selected from the group consisting of optically-active or racemic compounds represented by the general formula: ##STR1## wherein R.sub.1 is selected from the group consisting of organic radicals methyl, substituted or unsubstituted phenyls, pyridyl, hydroxphenyl, ##STR2## X is oxygen or sulfur, Y is selected from the group consisting of hydroxy, nitro, cyano, axido, amino, acylamino, carboxyamido, trifluoromethyl, sulfate, sulfonamido, halogen, hydrocarbyl and hetero atom-substituted hydrocarbyl radicals, wherein said heteroatoms are selected from the group consisting of halogen, nitrogen, oxygen, sulfur and phosphorus and said hydrocarbyl radicals comprise from 1 to 12 carbon atoms, and a is an integer of from zero to 3,
R.sub.2, R.sub.3 and R.sub.4 are each selected from the group consisting of H and OA, A is H or is selected from the group consisting of hydrocarbyl radicals, ##STR3## R.sub.5 is selected from the group consisting of hydrocarbyl radicals; n is an integer between 1 and 3; and R.sub.6 is an alkyl chain having between 1 and 3 carbon atoms with the provision that at least one of R.sub.2, R.sub.3 and R.sub.4 is H, that at least one of R.sub.2, R.sub.3 and R.sub.4 is not H, and that R.sub.2 and R.sub.4 are not both OA, and pharmaceutically acceptable salts thereof. Preferably, R.sub.2 is oxygen.
Preferably, R.sub.2 is OA and A is H, and the compound is the (-) isomer.
Baran Robert J.
Friedman Stanley J.
Hackler Walter A.
Whitby Research, Inc.
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