Surgery – Blood drawn and replaced or treated and returned to body – Constituent removed from blood and remainder returned to body
Reexamination Certificate
2000-10-26
2010-12-21
Bianco, Patricia (Department: 3772)
Surgery
Blood drawn and replaced or treated and returned to body
Constituent removed from blood and remainder returned to body
C604S004010, C604S008000, C604S006010, C210S638000, C210S645000, C210S767000, C424S085100, C424S145100, C128S898000
Reexamination Certificate
active
07854717
ABSTRACT:
A method to treat cancer uses ultrapheresis, refined to remove compounds of less than 120,000 daltons molecular weight, followed by administration of replacement fluid, to stimulate the patient's immune system to attack solid tumors. In the preferred embodiment, the patient is ultrapheresed using a capillary tube ultrafilter having a pore size of 0.02 to 0.05 microns, with a molecular weight cutoff of 120,000 daltons, sufficient to filter one blood volume. The preferred replacement fluid is ultrapheresed normal plasma. The patient is preferably treated daily for three weeks, diagnostic tests conducted to verify that there has been shrinkage of the tumors, then the treatment regime is repeated. The treatment is preferably combined with an alternative therapy, for example, treatment with an anti-angiogenic compound, one or more cytokines such as TNF, gamma interferon, or IL-2, or a procoagulant compound. The treatment increases endogenous, local levels of cytokines, such as TNF. This provides a basis for an improved effect when combined with any treatment that enhances cytokine activity against the tumors, for example, treatments using alkylating agents, doxyrubicin, carboplatinum, cistplatimum, and taxol. Alternatively, the ultrapheresis treatment can be combined with local chemotherapy, systemic chemotherapy, and/or radiation.
REFERENCES:
patent: 4116589 (1978-09-01), Rishton
patent: 4189470 (1980-02-01), Rose
patent: 4191182 (1980-03-01), Popovich et al.
patent: 4350156 (1982-09-01), Malchesky et al.
patent: 4362155 (1982-12-01), Skurkovich
patent: 4375414 (1983-03-01), Strahilevitz
patent: 4439332 (1984-03-01), Frank
patent: RE31688 (1984-09-01), Popovich et al.
patent: 4486282 (1984-12-01), Bier
patent: 4512763 (1985-04-01), Schneider
patent: 4581010 (1986-04-01), Skurkovich et al.
patent: 4605394 (1986-08-01), Skurkovich
patent: 4614513 (1986-09-01), Bensinger
patent: 4620977 (1986-11-01), Strahilevitz
patent: 4633417 (1986-12-01), Wilburn et al.
patent: 4634417 (1987-01-01), Korec
patent: 4664913 (1987-05-01), Mielke et al.
patent: 4708713 (1987-11-01), Lentz
patent: 4787974 (1988-11-01), Ambrus et al.
patent: 4801449 (1989-01-01), Balint, Jr. et al.
patent: 4813924 (1989-03-01), Strahilevitz
patent: 4824432 (1989-04-01), Skurkovich et al.
patent: 4834973 (1989-05-01), Strahilevitz
patent: 4863611 (1989-09-01), Bernstein
patent: 4865841 (1989-09-01), Balint, Jr. et al.
patent: 4963265 (1990-10-01), Okarma et al.
patent: 5037645 (1991-08-01), Strahilevitz
patent: 5037649 (1991-08-01), Balint, Jr. et al.
patent: 5078673 (1992-01-01), Abrams
patent: 5135919 (1992-08-01), Folkman et al.
patent: 5147638 (1992-09-01), Esmon et al.
patent: 5290807 (1994-03-01), Folkman et al.
patent: 5340736 (1994-08-01), Goldberg et al.
patent: 5356374 (1994-10-01), Hogan et al.
patent: 5359037 (1994-10-01), Wallach
patent: 5403917 (1995-04-01), Boos et al.
patent: 5523096 (1996-06-01), Okarma et al.
patent: 5565332 (1996-10-01), Hoogenboom et al.
patent: 5597899 (1997-01-01), Banner et al.
patent: 5605690 (1997-02-01), Jacobs et al.
patent: 5610279 (1997-03-01), Brockhaus
patent: 5621077 (1997-04-01), Novick et al.
patent: 5626843 (1997-05-01), Skurkovich et al.
patent: 5629327 (1997-05-01), D'Amato
patent: 5639725 (1997-06-01), O'Reilly et al.
patent: 5643732 (1997-07-01), Strahilevitz
patent: 5679260 (1997-10-01), Boos et al.
patent: 5698586 (1997-12-01), Kishimoto et al.
patent: 5705615 (1998-01-01), Lim et al.
patent: 5712291 (1998-01-01), D'Amato
patent: 5713491 (1998-02-01), Hughes et al.
patent: 5716981 (1998-02-01), Hunter et al.
patent: 5730713 (1998-03-01), Okarma et al.
patent: 5733876 (1998-03-01), O'Reilly et al.
patent: 5736138 (1998-04-01), Pfizenmaier et al.
patent: 5753227 (1998-05-01), Strahilevitz
patent: 5792845 (1998-08-01), O'Reilly et al.
patent: 5808029 (1998-09-01), Brockhaus
patent: 5817522 (1998-10-01), Goodman et al.
patent: 5817528 (1998-10-01), Bohm et al.
patent: 5840588 (1998-11-01), Strahilevitz
patent: 5861483 (1999-01-01), Wolpe
patent: 5869047 (1999-02-01), Blake
patent: 5888511 (1999-03-01), Skurkovich et al.
patent: 5910252 (1999-06-01), Truitt et al.
patent: 5919898 (1999-07-01), Nakatani et al.
patent: 5925633 (1999-07-01), Singh et al.
patent: 5932704 (1999-08-01), Jubinsky
patent: 5965394 (1999-10-01), Bandman et al.
patent: 5980887 (1999-11-01), Isner et al.
patent: 6017527 (2000-01-01), Maraskovsky et al.
patent: 6039946 (2000-03-01), Strahilevitz
patent: RE36755 (2000-06-01), Smith et al.
patent: 6133431 (2000-10-01), Yasuda
patent: 6197289 (2001-03-01), Wirt et al.
patent: 6221614 (2001-04-01), Prusiner et al.
patent: 6231536 (2001-05-01), Lentz
patent: 6232446 (2001-05-01), Wallach
patent: 6245038 (2001-06-01), Borberg et al.
patent: 6262127 (2001-07-01), Acemoglu et al.
patent: 6264623 (2001-07-01), Strahilevitz
patent: 6287516 (2001-09-01), Matson et al.
patent: 6379708 (2002-04-01), Howell et al.
patent: 6428790 (2002-08-01), Boyd
patent: 6432405 (2002-08-01), Weinberg et al.
patent: 6528057 (2003-03-01), Ambrus et al.
patent: 6561997 (2003-05-01), Weitzel et al.
patent: 6569112 (2003-05-01), Strahilevitz
patent: 6602502 (2003-08-01), Strahilevitz
patent: 6602993 (2003-08-01), Wallach et al.
patent: 6607501 (2003-08-01), Gorsuch
patent: 6607723 (2003-08-01), Good et al.
patent: 6620382 (2003-09-01), Lentz
patent: 6627151 (2003-09-01), Borberg et al.
patent: 6630315 (2003-10-01), Miwa et al.
patent: 6676622 (2004-01-01), Strahilevitz
patent: 6685664 (2004-02-01), Levin et al.
patent: 6720155 (2004-04-01), Lopez et al.
patent: 6774102 (2004-08-01), Bell et al.
patent: 6824986 (2004-11-01), Finkelman et al.
patent: 6866846 (2005-03-01), Heinrich et al.
patent: 6878127 (2005-04-01), Brady et al.
patent: 6982089 (2006-01-01), Tobinick
patent: 7105484 (2006-09-01), Klein et al.
patent: 7196070 (2007-03-01), Sukumar
patent: 7238776 (2007-07-01), Hauptmann
patent: 7368295 (2008-05-01), Tovar et al.
patent: 2001/0010818 (2001-08-01), Engle et al.
patent: 2001/0039392 (2001-11-01), Strahilevitz
patent: 2002/0019603 (2002-02-01), Strahilevitz
patent: 2002/0058031 (2002-05-01), Tung et al.
patent: 2002/0086276 (2002-07-01), Srivastava
patent: 2002/0107469 (2002-08-01), Bolan et al.
patent: 2002/0111577 (2002-08-01), Sirimanne et al.
patent: 2002/0114728 (2002-08-01), Kulish et al.
patent: 2002/0119147 (2002-08-01), Howell et al.
patent: 2002/0159995 (2002-10-01), Brady et al.
patent: 2002/0183677 (2002-12-01), Chang et al.
patent: 2002/0187069 (2002-12-01), Levin et al.
patent: 2002/0197249 (2002-12-01), Brady et al.
patent: 2002/0197250 (2002-12-01), Brady et al.
patent: 2002/0197251 (2002-12-01), Brady et al.
patent: 2003/0073822 (2003-04-01), Lofling et al.
patent: 2003/0115854 (2003-06-01), Glenn et al.
patent: 2003/0125657 (2003-07-01), Koll et al.
patent: 2003/0127390 (2003-07-01), Davis, Jr.
patent: 2003/0129130 (2003-07-01), Guire et al.
patent: 2003/0133929 (2003-07-01), Cham
patent: 2003/0138349 (2003-07-01), Robinson et al.
patent: 2003/0148404 (2003-08-01), Michaelson
patent: 2003/0163077 (2003-08-01), Kim et al.
patent: 2003/0195452 (2003-10-01), Hunley et al.
patent: 2003/0215443 (2003-11-01), Coffey et al.
patent: 2004/0044301 (2004-03-01), Levin et al.
patent: 2004/0054315 (2004-03-01), Levin et al.
patent: 2005/0244371 (2005-11-01), Lentz
patent: 2005/0265996 (2005-12-01), Lentz
patent: 2007/0065514 (2007-03-01), Howell et al.
patent: 2008/0057060 (2008-03-01), Lentz
patent: 2008/0075690 (2008-03-01), Howell et al.
patent: 2008/0145333 (2008-06-01), Lentz
patent: 2008/0275376 (2008-11-01), Howell et al.
patent: 2107340 (1992-12-01), None
patent: 3302384 (1983-01-01), None
patent: 43 45 200 (1994-12-01), None
patent: 196 24 250 (1998-01-01), None
patent: 0 184 040 (1986-06-01), None
patent: 0076665 (1987-01-01), None
patent: 289896 (1992-07-01), None
patent: 334165 (1995-12-01), None
patent: 787500 (1999-12-01), None
patent: 589982 (2001-01-01), None
patent: 2136314 (1984-09-01), None
patent: 56092824 (1981-07-01), None
patent: 02045064 (1990-02-01), None
patent: 6 296860 (1994-10-01), None
patent: 2 130 069 (1999-05-01), None
patent: WO 7
Bianco Patricia
Biopheresis Technologies, Inc.
Clark & Elbing LLP
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