Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1994-05-20
2000-05-23
Eyler, Yvonne
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 724, 435 72, 435 71, 436 63, 436 64, G01N 33574, G01N 3353, G01N 3348
Patent
active
060664630
ABSTRACT:
The present invention relates to compositions and methods for the prevention and treatment of cell proliferative disorders wherein a protein tyrosine kinase or protein tyrosine phosphatase capable of complexing with a member of the SH2- and/or SH3-containing family of adaptor proteins is involved. This invention is based, in part, on the surprising discovery that the adaptor protein, GRB-2, binds the intracellular BCR-ABL tyrosine kinase product in vivo and is necessary for the activation of the oncogenic potential of the BCR/ABL product. The present invention further relates to protein tyrosine kinase/adaptor protein complexes and the uses of these complexes for the identification of agents capable of decreasing or inhibiting the interaction between the members of such complexes.
REFERENCES:
Shepard et al., "Monoclonal antibody therapy of human cancer:taking the HER2 protooncogene to the clinic" vol. 11, No. 3, p. 117-127, Journal of Clinical Immunology, 1991.
Fialkow et al., 1977, "Chronic myelocytic leukemia: clonal origin in a stem cell common to the granulocyte, erythrocyte, platelet and monocyte/macrophage," Am. J. Med. 63:125-130.
Konopka et al., 1984, "An alteration of the human c-abl protein in K562 leukemia cells unmasks associated tyrosine kinase activity," Cell 37:1035-1042.
Kruh et al., 1986, "A novel human gene closely related to the abl proto-oncogene," Science 234:1545-1548.
Sadowski et al., 1986, "A noncatalytic domain conserved among cytoplasmic protein-tyrosine kinases modifies the kinase function and transforming activity of Fujinami sarcoma virus P130gag-fps," Mol. and Cell. Biol. 6:4396-4408.
Shtivelman et al., 1986, "Alternative splicing of RNAs transcribed from the human abl gene and from the bcr-abl fused gene," Cell 47:277-284.
Kurzrock et al., 1988, "The molecular genetics of Philadelphia chromosome-positive leukemias," N. Engl. Med. 319:990-998.
Mayer et al., 1988, "A novel viral oncogene with structural similiarity to phospholipase C," Nature 332:272-275.
Rosenberg et al., 1988, "The viral and cellular forms of the Abelson (abl) oncogene," Advances in Virus Research 35:39-81.
Timmons et al., 1989, "Structural characterization of the BCR gene product," Oncogene 4:559-567.
Hardie 1990, "Roles of protein kinases and phosphatases in signal transduction," Symp. Soc. Exp. Biol. 44:241-255.
Nurse et al., 1990, "Universal control mechanism regulating onset of M-phase," Nature 344:503-508.
Ullrich et al., 1990, "Signal transduction bby receptors with tyrosine kinase activity," Cell 61:203-212.
Wilks et al., 1990, "Structure and function of the protein tyrosine kinases," Progress in Growth Factor Research 2:97-111.
Cantley et al., 1991, "Oncogenes and signal transduction," Cell 64:281-302.
Fischer et al., 1991, "Protein tyrosine phosphatases: a diverse family of intracellular and transmembrane enzymes," Science 253:401-406.
Hunter et al., 1991, "Cooperation between oncogenes," Cell 64:249-270.
Koch et al., 1991, "SH2 and SH3 domains: elements that control interactions of cytophasmic signaling proteins," Science 252:668-674.
McWhirter et al., 1991, "Activation of tyrosine kinase and the microfilament-binding functions of c-abl by bcr sequences in bcr/abl fusion proteins," Mol. and Cell. Biol. 11:1553-1565.
Muller et al., 1991, "BCR first exon sequences specifically activate the BCR/ABL tyrosine kinase oncogene of Philadelphia chromosome-positive human leukemias," Mol. and Cell. Biol. 11:1785-1792.
Pendergast et al., 1991, "BCR sequences essential for transformation by the BCR-ABL oncogene bind to the ABL SH2 regulatory domain in a non-phosphotyrosine-dependent manner," Cell 66:161-171.
Pendergast et al., 1991, "Evidence for regulation of the human ABL tyrosine kinase by a cellular inhibitor," Proc. Nat. Acad. Sci. USA 88:5927-5931.
Bowtell et al., 1992, "Identification of murine homologues of the Drosophila Son of Sevenless gene: potential activators of Ras," Proc. Nat. Acad. Sci. USA 89:6511-6515.
Lowenstein et al., 1992, "The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling," Cell 70(3):431-442.
Lowenstein et al., 1992, "The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling," Cell 70:431-442.
Muller et al., 1992, "A limited set of SH2 domains binds BCR through a high affinity phosphotyrosine-independent interaction," Mol. and Cell. Biol. 12:5087-5093.
Pawson et al., 1992, "SH2 and SH3 domains:from structure to function," Cell 71:359-362.
Posada et al., 1992, "Molecular signal integration. Interplay between serine, threonine, and tyrosine phosphorylation," Mol. Biol. Cell. 3:583-592.
Sarzani et al., 1992, "A novel endothelial tyrosine kinase cDNA homologous to platelet-derived growth factor receptor cDNA," Biochem. Biophys. Res. Commun. (United States) 186(2):706-714.
Schlessinger et al., 1992, "Growth factor signaling by receptor tyrosine kinases," Neuron 9:383-391.
Zhang et al., 1992 "Activation of phospholipase D by platelet-derived growth factor (PDGF) in rat C6 glioma cells: possible role in mitogenic signal transduction," Neurol. Res. (England) 14(5):397-401.
Buday et al., 1993, "Epidermal growth factor regulates p21.sup.Ras through the formation of a complex receptor, Grb2 adaptor protein, and Sos nucleotide exchange factor," Cell 73:611-620.
Chardin et al., 1993, "Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2", Science 260:1338-1343.
Egan et al., 1993, "Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation," Nature 363:45-51.
Gale et al., 1993, "Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras," Nature 363:88-92.
Li et al., 1993, "Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling," Nature 363:85-87.
Liu et al., 1993, "BCR-ABL tyrosine kinase is autophosphorylated or transphosphorylates P160 BCR on tyrosine predominantly within the first BCR exon," Oncogene 8:101-109.
Lowy et al., 1993, "Function and regulation of Ras," Ann. Rev. Biochem. 62:851-891.
Olivier et al., 1993, "A Drosophila SH2-SH3 adaptor protein implicated in coupling the Sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos," Cell 73:179-191.
Rozakis-Adcock et al., 1993, "The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1," Nature 363:83-85.
Schlessinger et al., 1993, "How receptor tyrosine kinases activate Ras," TIBS 18:273-275.
Simson et al., 1993, "An SH3-SH2-SH3 protein is required for p21.sup.Ras1 activation and binds to Sevenless and Sos proteins in vitro," Cell 73:169-177.
Skorski et al., 1993, "Highly efficient elimination of Philadelphia leukemia cells by exposure to bcr/abl antisense oligodeoxynucleotides combined with mafosfamide," J. Clin. Invest. 92:194-202.
Snyder et al., 1993, "Ribozyme-mediated inhibition of bcr/abl gene expression in a Philadelphia chromosome-positive cell line," Blood 82:600-605.
Liebow et al., 1989, "Somatostatin analogues inhibit growth of pancreatic cancer by stimulating tyrosine phosphatase", Proc. Natl. Acad. Sci. USA 86:2003-2007.
Freidinger, 1989, "Non-peptide ligands for peptide receptors", TIPS Reviews 10:270-274.
Pelicci et al., 1992, "A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction", Cell 70:93-104.
Rozakis-Adcock et al., 1992, "Association of the Shc and grb2/sem5 SH2-containing proteins is implicated in activation of the ras pathway by tyrosine kinases", Nature 360:689-692.
Pawson and Schlessinger, 1993, "SH2 and SH3 domains", Curr. Biol. 3:434-442.
Pendergast et al., 1993, "BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein", Cell 75:175-185.
Skolnik et al., 1993, "The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine--phosphorylated IRS1 and Shc: implications for insulin control of ras signalling", EMBO J. 12:1929-1936.
Gishizky Mikhail L.
Pendergast Ann Marie
Schlessinger Joseph
Duke University
Eyler Yvonne
New York University
Sugen Inc.
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