Method and compositions for treating pneumocystic carini infecti

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

A61K 3119

Patent

active

051589796

ABSTRACT:
The present invention provides methods for treating and preventing the onset of Pneumocystis carinii pneumonia (PCP) comprising administering to a mammal in need to such treatment or prevention an effective amount of a pharmaceutically acceptable iron chelator. This invention also provides a method for treating or preventing the onset of PCP comprising administering to a mammal in need of such treatment or prevention a composition comprising the following components: (a) a pharmaceutically acceptable iron chelator; (b) a compound selected from trimethoprim/sulfamethoxazole and pentamidine; and (c) a pharmaceutically compatible carrier or diluent, wherein the amounts of said component (a) and said component (b) in combination are effective in treating said pneumonia. Also provided is a composition for the treatment or prevention of PCP.

REFERENCES:
patent: 2410796 (1986-11-01), Easson
patent: 3049544 (1962-08-01), Stenbuck
patent: 3341541 (1967-09-01), Hoffer
patent: 4119365 (1983-12-01), McLachlan
patent: 4614797 (1986-09-01), Nagata et al.
Medline 05277726 (1984)-Louy et al.
Pascal 0564322 (1983)-Vanderbergh et al.
Hawlliwell et al., "The Importance of Free Radicals and Catalytic Metal Ions in Human Diseases" (1985), Univ. of London King's College.
Chem Abst., 109:206351t (1988), Fukuyasu.
Chem. Abst. 91:68456n (1979), Zgorniak-Nowosielska et al.
Chem. Abst. 89:5642 (1978), Yoshida et al.
Hughes, W. T., N. Eng. J. Med., 317:1021-1023 (1987).
Edman, J. C., et al., Nature 334:519-522, 1988.
Haverkos, H. W., Am. J. Med. 76:501-508, 1984.
Green, et al., British Journal of Clinical Pharmacology 26:487-491, 1988.
Allegra, et al., New England Journal of Medicine 317:978-985, 1987.
Gallacher, et al., Critical Care Medicine 17:104-105, 1989.
Sattler, et al., Annals of Internal Medicine 109:280-287, 1988.
Kovacs and Masur, Journal of Infectious Diseases 158:254-259, 1988.
Clarkson, et al., Antimicrobial Agents and Chemotherapy 32:1158-1163, 1988.
Queener, et al., Antimicrobial Agents and Chemotherapy 31:1323-1327, 1987.
Queener, et al., Antimicrobial Agents and Chemotherapy 32:807-813, 1988.
Masawe, A. E. J., et al., Lancet, 2:314-317, 1974.
Hynes, J. B., J. Med. Chem. 13: 1235-1237, 1970.
Pollack, S., et al., Proc. Soc. Exp. Biol. Med. 184: 162-164, 1987.
Raventos-Suraez, C., et al., 1982, Am. J. Trop. Med. Hyg. 3 (5:919-922.
Fritsch, G., et al., 1985, Exp. Parisitol 60:171-174.
Graziano, J. H., et al., 1978, J. Ped, 92 (4):648-652.
Peto, T. E. A. and J. L. Thompson, 1986, Br. J. Haematol 63:273-280.
Jones, R. L. and R. W. Grady, 1983, Eur. J. Clin. Microbiol. 2:411-413.
Youdim, S., 1969, Am. Rev. Resp. Dis. 99:925-931 (Abstract only).
Schafer, A. I. and K. Bridges 1985, Arch. Intern. Med. 145:1217-1221.
Franklin D. Lowy, et al., "Susceptibilities of Bacterial and Fungal Urinary Tract Isolates to Desferrioxamine", Animicrob. Agents Chemotherap. vol. 25, No. 3, Mar. 1984, pp. 375-376.
Peter A. Vandenbergh, et al., "Iron-Chelating Compounds Produced by Soil Pseudomonads: Correlation with Fungal Growth Inhibition", App. and Environ. Micro. vol. 46, No. 1, Jul. 1983, pp. 128-132.
Teri Gallant, et al., "Yersinia Sepsis in Patients with Iron Overload Treated With Deferoxamine" New Eng. J. Med., vol. 314, No. 25, 1986, p. 1643.
H. Y. Chiu, et al., "Infection With Yersinia Enterocolitica in Patients With Iron Overload", Brit. Med. J., vol. 292, Jan. 11, 1986, p. 97.
P. A. Kouides, et al. "Pneumocystis Carinii Pneumonia As a Complication for Desferrioxamine Therapy", Brit. J. Haematol., vol. 70, 1988, pp. 382-383.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Method and compositions for treating pneumocystic carini infecti does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method and compositions for treating pneumocystic carini infecti, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method and compositions for treating pneumocystic carini infecti will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-905837

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.