Method and compositions for treating arthritis

Details Method and compositions for treating arthritis Method and compositions for treating arthritis

1996-10-22

1999-08-24

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 12, 514 14, 4242121, 4242061, A61K 3804, A61K 3808, A61K 39165, A61K 39145

Patent

active

059424915

ABSTRACT:
The present invention provides a process for the treatment of arthritis including the step of administering to an animal or human patient in need of such treatment a plurality of peptides each of which peptides contains a sequence of amino acid residues that is identical to or homologous to residues 110-121 or 152-161 of myelin basic protein. Novel peptides for use in that process are also provided.

REFERENCES:
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patent: 5194425 (1993-03-01), Sharma et al.
patent: 5260422 (1993-11-01), Clark et al.
Proost, Paul et al., "Leukocyte Gelatinase B Cleavage Releases Encephalitogens From Human Myelin Basic Protein," Biochemical and Biophysical Research Communications 192(3):1175-1181 (1993).
Yamamura et al., J. of Neuroscience Research 45(6):706-713 (1996).
Malleson et al., Arthritis Rheum. 35(9): Suppl. S137 (1992).
Pelton et al., Clin. Exp. Immunol. 62(3):657-661 (1985).
Hogervorst et al., Infect. Immun. 59(6):2029-2035 (1991).
Dayhoff, M.O. Atlas of Protein Sequences and Structures, vol. 5, p. 96, Jan. 1972.
Malleson et al. Arthritis Rheum. 35, No. 9, Suppl. S137, Sep. 1992.
Hogervorst et al. Infect Immun. 59(6), 2029-35, Jun. 1991.
Pelton et al. Clin. Exp. Immunol 62 (3) 657-661, Mar. 1985.

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