Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Conjugate or complex
Patent
1997-10-16
1999-12-28
Saunders, David
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Conjugate or complex
424810, 4241841, 514 2, 514825, 514866, 514903, 530350, 530806, 530827, 530868, A61K 3900, A61K 39385, A01N 3718, C07K 14435
Patent
active
060078219
ABSTRACT:
The invention relates to methods and compositions for the treatment of autoimmune disease. Specifically, compositions comprising heat shock proteins, including gp96, hsp90, and hsp70, are disclosed. Immunotherapeutic methods for administering the hsp-containing compositions are disclosed. Furthermore, methods for preventing rejection of organs transplanted to treat autoimmune disease are disclosed. The disclosed methods are useful for treating a variety of autoimmune diseases, including insulin dependent diabetes mellitus.
REFERENCES:
patent: 5268170 (1993-12-01), Van Eden et al.
patent: 5354691 (1994-10-01), Van Eden et al.
patent: 5578303 (1996-11-01), Cohen et al.
patent: 5750119 (1998-05-01), Srivastava
patent: 5830464 (1998-11-01), Srivastava
patent: 5837251 (1998-11-01), Srivastava
Tisch, R and McDevitt, HO. Proc. Nat. Acad. Sci. (USA) 91:437-438, Jan. 1994.
Tamura, Y. et al. Science 278:117-120. Oct. 1997.
Nieland, TJF et al. Proc. Nat. Acad. Sci. (USA) 93:6135-6139. Jun. 1996.
Suto, R et al. Science 269:1585-1588, Sep. 1995.
Adamec et al., 1996, "Development of the Surgical Technique and Tactics of Combined Pancreas and Kidney Transplantation With Respect to the Incidence of Surgical Complications", Transplantation Proceedings 28-6:3347.
Akhtar et al., 1995, "CD4.sup.+ .beta. islet cell-reactive T cell clones that supress autoimmune diabetes in nonobese diabetic mice", J. Exp. Med. 182:87-97.
Bardwell et al., 1984, "Major heat shock gene of Drosophila and the Escherichia coli heat inducible dnaK gene are homologous", Proc. Natl. Acad. Sci. 81:848-852.
Blachere et al., 1993, "Heat Shock Protein Vaccines Against Cancer", J. of Immunotherapy 14:352-356.
Birk et al., 1993, "T-Cell autoimmunity in type 1 diabetes mellitus", Current Opinion in Immunology 5:903-909.
Birk et al., 1996, "NOD Mouse Diabetes: The Ubiquitous Mouse Hsp60 is a .beta.-Cell Target Antigen of Autoimmune T Cells", J. of Autoimmunity 9:159-166.
Birk et al., 1996, "A role of Hsp60 in autoimmune diabetes: Analysis in a transgenic model", P.N.A.S. 93:1032-1037.
Bockova et al., 1997, "Treatment of NOD Diabetes with a Novel Peptide of the Hsp60 Molecule Induces Th2-type Antibodies", J. of Autoimmunity 10:323-329.
Bohme et al., 1990, "MHC-linked protection from diabetes dissociated from clonal delection of T cells", Science 249:293-295.
Boitard et al., 1989, "T cell-mediated inhibition of the transfer of autoimmune diabetes in NOD mice", J. Exp. Med. 169:1669-1680.
F.C. Brunicardi, 1996, "Clinical islet transplantation: A consortium model", Transplantation Proceedings 28:2138-2140.
Castano and Eisenbarth, 1990, "Type-I diabetes: A chronic autoimmune disease of human, mouse, and rat", Annu. Rev. Immunol. 8:647-679.
Chosich and Harrison, 1993, "Suppression of diabetes mellitus in the non-obese diabetic (NOD) mouse by an autoreactive (anti-I-A.sup.g7) islet-derived CD4.sup.+ T-cell line", Diabetologia 36:716-721.
Cohen R.C. et al., 1991, "Autoimmunity to the Chaperonins in the Pathogenesis of Arthritis and Diabetes" Ann. Rev. Immunol. 9:567-589.
Cohen R.C., 1992, "Immunologically Specific Treatment of Spontaneous Insulin-dependant Diabetes Mellitus of NOD Mice" J. of Autoimmunity 5:227-230 (Supplement A).
Cohen R.C., 1997, Short Analytical Review; The Th1-Th2 Dichotomy, hsp60 Autoimmunity, and Type 1 Diabetes Clin. Immuno. and Immunopathology 84-2:103-106.
Cohen R.C. et al., 1996, "Immunity to 60kDa heat shock protein in autoimmune diabetes" Diab. Nutr. Metab. 9:229-232.
Cohen R.C. et al., 1992, "Autoimmunity to Hsp65 and the Immunologic Paradigm*", Advances In Internal Medicine 37:295-311.
E.A. Craig, 1993, "Chaperones: Helpers along the pathways to protein folding", Science 260:1902-1903.
Demotz et al., 1989, "Characterization of a naturally processed MHC class II-restricted T-cell determinant of hen egg lysozyme", Nature 342:682-684.
Elias and Cohen, 1994, "Peptide therapy for diabetes in NOD mice", Lancet 343:704-706.
Elias et al.,1994, "Autoimmune Diabetes Induced by the .beta.-Cell Toxin STZ; Immunity to the 60-kDa Heat Shock Protein and to Insulin", Diabetes 43:992-998.
Elias et al., 1990, "Induction and therapy of autoimmune diabetes in the non-obese diabetic (NOD/Lt) mouse by a 65-kDA heat shock protein", Proc. Natl. Acad. Sci. 87:1576-1580.
Elias et al., 1991, "Vaccination against autoimmune mouse diabetes with a T-cell epitope of the human 65-k-Da heat shock protein", Proc. Natl. Acad. Sci. 88:3088-3091.
Elias et al., 1995, "Induction of diabetes in standard mice by immunization with the p277 peptide of a 60-kDa heat shock protein", Eur. J. Immunol. 25:2851-2857.
Elias and Cohen, 1995, "Treatment of autoimmune diabetes and insulitis in NOD mice with heat shock portein 60 peptide p277", Diabetes 44:1132-1138.
Elias et al., 1996, "The hsp60 Peptide p227 Arrests the Autoimmune Diabetes Induced by the Toxin Streptozotocin" Diabetes 45:1168-1172.
Elliott et al., 1990, "Naturally processed peptides", Nature 348:195-197.
Falk et al., 1990, "Cellular peptide composition governed by major histocompatibility complex class I molecules", Nature 348:248-251.
Falk et al., 1991, "Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules", Nature 351:290-296.
Feige et al., 1994, "A Constitutive 65 Kda Chondrocyte Protein as a Target Antigen in Adjuvant Arthritis in Lewis Rats"Autoimmunity 17:233-239.
Feige et al., 1996, "Infection, autoimmunity and autoimmune disease" Stress Inducible Cellular Responses eds. Birkhauser Velag Basel, Switzerland.
Gething and Sambrook, 1992, "Protein folding in the cell", Nature 355:33-45.
Hamaguchi and Leiter, 1990, "Comparison of cytokine effects on mouse prancreatic .alpha.-cell and .beta.-cell lines", Diabetes 39:415-425.
Hamano et al., 1996, "Pancreas transplantation using non-suture cuff technique in the neck", Kobe J. Med. Sci. 42:93-104.
Haskins and McDuffie, 1990, "Acceleration of diabetes in young NOD mice with a CD4.sup.+ islet-specific T cell clone", Science 249:1433-1436.
Heufelder et al., 1992, "Cell Surface Localization of a 72 Kilodalton Heat Shock Protein in Retroocular Fibroblasts from Patients with Graves Ophthalmopathy" J. of Clin. Endocrino. And Metabolism 74-4:732-736.
Hickey et al., 1989, "Sequence and regulation of a gene encoding a human 89-kilodalton heat shock protein", Molecular and Cellular Biology 9:2615-2626.
Hunt and Morimoto, 1985, "Conserved features of eukaryotic hsp70 genes revealed by comparison with the nucleotide sequence of human hsp70", Proc. Natl. Acad. Sci. 82:6455-6459.
Jindal et al., 1989, "Primary structure of a human mitochondrial protein homologous to the bacterial and plant chaperonins and to the 65-kilodalton mycobacterial antigen", Molecular and Cellular Biology 9:2279-2283.
Jones David.B. et al., 1993, "Sequence homologies between hsp60 and autoantigens" Immunology Today 14-3:115-118.
Kaufman et al., 1993, "Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes", Nature 366:69-71.
Kendall et al., 1996, "Pancreas and islet transplantation in humans", Diabetes & Metabolism (Paris) 22:157-163.
Kinkhabwala et al., 1996, "The role of whole organ pancreas transplantation in the treatment of type I diabetes", The American Journal of Surgery 171:516-520.
Konen-Waisman et al., 1995, "Self and Foreign 60-Kilodalton Heat Shock Protein T Cell Epitope Peptides Serve as Immunogenic Carriers for a T Cell-Independent Sugar Antigen" J. of Immunology 154:5977-5985.
Lai et al., 1984, "Quantitation and intracellular localization of the 85K heat shock protein by using monoclonal and polyclonal antibodies", Molecular and Cellular Biology 4:2802-2810.
Larsen and Stratta, 1996, "Pancreas transplantation: A treatment option for insulin-dependent diabetes mellitus", Diabetes & Metabolism (Paris) 22:139-146.
Levy et al., 1991, "ATP is required for in vitro assembly of MHC class I antigens but not for transfer of peptides across the ER membrane", Cell 67:265-274.
Li and Srivastava, 1993, "Tumor rejection antigen gp96/grp94 is an ATPase: Implications for protein folding and antigen p
Chandawarkar Rajiv Y.
Srivastava Pramod K.
Fordham University
Saunders David
VanderVegt F. Pierre
LandOfFree
Method and compositions for the treatment of autoimmune disease does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method and compositions for the treatment of autoimmune disease , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method and compositions for the treatment of autoimmune disease will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2380505