Method and compositions for the synthesis of BCH-189 and related

Details Method and compositions for the synthesis of BCH-189 and related Method and compositions for the synthesis of BCH-189 and related

1990-02-01

1993-04-20

Tsang, Cecilia

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544310, 544212, 544276, 544277, 544313, 544229, 544314, 549 4, 549 30, C07D41104, C07D47300, C07F 502

Patent

active

052044661

ABSTRACT:
The present invention relates to a method of preparing BCH-189 and various analogs of BCH-189 from inexpensive precursors with the option of introducing functionality as needed. This synthetic route allows the stereoselective preparation of the biologically active isomer of these compounds, .beta.-BCH-189 and related compounds. Furthermore, the steochemistry at the nucleoside 4' position can be controlled to produce enantiomerically-enriched .beta.-BCH-189 and its analogs.

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