Drug – bio-affecting and body treating compositions – Lymphokine
Patent
1993-11-29
1997-10-28
Smith, Lynette F.
Drug, bio-affecting and body treating compositions
Lymphokine
424 852, 530395, 514 8, A61K 4505, A61K 3816, C07K 100, C07K 1400
Patent
active
056815565
ABSTRACT:
Disclosed herein are methods for suppressing allograft rejection in mammals comprising administering to a mammal about to undergo or having undergone allograft surgery an agent selected from the group consisting of splenic tissue from an allograft donor, splenic extracts, cultured lymphocytes from an allograft donor, extracts of said cultured lymphocytes, MHC antigens, transplantation rejection suppressive fragments and analogs of MHC antigens in an oral or aerosol form. Also disclosed herein are pharmaceutical formulations and dosage forms for use in said methods.
REFERENCES:
patent: 4635627 (1987-01-01), Gam
patent: 5130297 (1992-07-01), Sharma et al.
Mason D.W. et al., Ann. Rev. Immunol. 4:119-145, 1986.
Mowat et al., Immunol. Today 8(3):93-98, 1987.
Chao et al., Immunogenetics 29:231-234, 1989.
Krensky et al., New Eng. J. Med. 32:510-517, 1990.
Prochazka et al. Science 237:286, 1987.
Bendelac, A. et al., J. Exp. Med. 166:823, 1987.
Nagler-Anderson, et al., Proc. Natl. Acad. Sci. (USA) 83: 7443-7446, 1986.
Tilney, N.L. et al. J. Immunol. 121:1480, 1978.
Hendry, W.S., et al., J. Exp. Med. 149:1042, 1979.
Chao, Nelson J. et al. Immunogenetics 29:231-234, 1989.
Hutchinson, Transplanation 41:549, 1986.
Frankel et al Transplantation 48:639, 1989.
Clarke, S.W. and Davia, D. eds., Aerosols and the Lung, pp. 197-224, Butter-worths, London, England, 1984.
Wood, et al., 1985, "Suppression of Renal Allograft Rejection in the Rat . . . " Transplantation 39(1): 56-62.
Newman, 1984, "Therapeutic Aerosols", Clarke & Davia eds. Aerosols and the Lung pp. 197-224.
Higgins, et al. 1988, "Suppression of Experimental Autoimmune . . . " J. Immunol, 140(2):440-445.
Richman, et al., 1978, "Enterically Induced Immunologic Tolerance". J. Immunol. 121(6):2429-2434.
Milton, et al, 1985, "Massive Induction of Donor-Type . . . " J. Exp. Med. 161: 98 -112.
Remington's Pharmaceutical Sciences, 1948, :1633-1634, 1658-59, 1664-65, 1694-95.
Richman, et al, 1978, J. Immunol. 121(6): 2429-2434.
Higgins, et al, 1988, J. Immunol. 140(2):440-445.
Head, J.R. et al., Transplant. Proc. 9:1465-1471, 1977.
Hancock, W.W. et al., Transplantation 55:1112-8, 1993.
Sayegh, M.H. et al., American Society of Histocompatability and Immunogenics, 18th Annual Meeting, Abstract, Oct. 1992.
Sayegh, M.H. et al., American Society of Nephrology, 25th Annual Meeting, Abstract, Nov. 1992.
Sayegh, M.H. et al., Proc. Nat'l. Acad. Sci. (U.S.A.) 89: 7762-9, 1992.
Sayegh, M.H. et al., Transplantation 53:163-6, 1992.
Carpenter Charles B.
Hafler David Allen
Sayegh Mohamed
Weiner Howard L.
Zhang Zhengyi
Autoimmune Inc.
Smith Lynette F.
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