Method and compositions for solubilization and stabilization of

Details Method and compositions for solubilization and stabilization of Method and compositions for solubilization and stabilization of

1989-06-29

1999-12-07

Russel, Jeffrey E.

Drug, bio-affecting and body treating compositions

Lymphokine

Interleukin

514 2, A61K 3820, A61K 4726

Patent

active

059978562

ABSTRACT:
The invention provides a method for the solubilization and/or stabilization of polypeptides, especially proteins, using cyclodextrin selected from the group consisting of hydroxypropyl, hydroxyethyl, glucosyl, maltosyl and maltotriosyl derivatives of .beta.- and .gamma.-cyclodextrin. Solubilized and/or stabilized compositions comprising a polypeptide, especially a protein, and the selected cyclodextrin are also described.

REFERENCES:
patent: 3459731 (1969-08-01), Gramera et al.
patent: 4024223 (1977-05-01), Noda et al.
patent: 4228160 (1980-10-01), Szejtli et al.
patent: 4232009 (1980-11-01), Hayashi et al.
patent: 4351846 (1982-09-01), Matsumoto et al.
patent: 4352793 (1982-10-01), Yamahira et al.
patent: 4383992 (1983-05-01), Lipari
patent: 4407795 (1983-10-01), Nicolau et al.
patent: 4424209 (1984-01-01), Tuttle
patent: 4425336 (1984-01-01), Tuttle
patent: 4438106 (1984-03-01), Wagu et al.
patent: 4457916 (1984-07-01), Hayashi et al.
patent: 4474811 (1984-10-01), Masuda et al.
patent: 4478995 (1984-10-01), Shinoda et al.
patent: 4479944 (1984-10-01), Hayashi et al.
patent: 4479966 (1984-10-01), Hayashi et al.
patent: 4497803 (1985-02-01), Harada et al.
patent: 4499085 (1985-02-01), Masuda
patent: 4505893 (1985-03-01), Mori et al.
patent: 4518588 (1985-05-01), Szejtli et al.
patent: 4524068 (1985-06-01), Szejtli et al.
patent: 4552760 (1985-11-01), Murakami et al.
patent: 4555504 (1985-11-01), Jones
patent: 4565807 (1986-01-01), Uekama et al.
patent: 4568544 (1986-02-01), Hasegawa et al.
patent: 4575548 (1986-03-01), Ueda et al.
patent: 4596795 (1986-06-01), Pitha
patent: 4598070 (1986-07-01), Ohwaki et al.
patent: 4603123 (1986-07-01), Chiesi et al.
patent: 4608366 (1986-08-01), Hasegawa et al.
patent: 4623641 (1986-11-01), Szejtli et al.
patent: 4659696 (1987-04-01), Hirai et al.
patent: 4663316 (1987-05-01), Ninger et al.
patent: 4675395 (1987-06-01), Fukazawa et al.
patent: 4727064 (1988-02-01), Pitha
patent: 4728509 (1988-03-01), Shimizu et al.
patent: 4728510 (1988-03-01), Shibanai et al.
patent: 4751095 (1988-06-01), Karl et al.
patent: 4764604 (1988-08-01), Muller
patent: 4897472 (1990-01-01), Korpela et al.
patent: 4925678 (1990-05-01), Ranney
patent: 4983586 (1991-01-01), Bodor
Grand and Hackh's Chemical Dictionary, Fifth Ed., p. 431 (1987).
Brewster et al., Pharmaceutical Res., vol. 8, No. 6 pp. 792-795 (1991).
Uekama, 1987, topics in Pharmaceutical Sciences 181-194.
Okada et al., 1988, Chem. Pharm. Bull. 36:2176-2185.
Koizumi et al., 1987, Chem. Pharm. Bull. 35:3413-3418.
Yamamoto et al., 1989, Intl. Journal of Pharmaceutics 49:163-171.
Wang et al., 1988, Parenteral Formulations of Proteins and Peptides: Stability and Stabilizers 42:2S-S26.
Uekama, Mar., 1985, Pharmacy International pp. 61-65.
Pitha, 1984, J. Inclusion Phenomena 2:477-485.
Fenyvesi, 1984, Chem. Pharm. Bull. 32(2):665-669.
Uekama et al., 1985, International Journal of Pharmaceutics 23:35-42.
Pitha et al., 1985, J. Pharmaceutical Sciences 74(9):987-990.
Pitha et al., 1986, International J. Pharmaceutics 29:73-82.
Uekama et al., 1987, CRC Critical Reviews in Therapeutic Drug Carrier Systems 3(1):1-40.
Okada et al., 1988, Chem. Pharm. Bull. 36(6):2176-2185.

Affiliated with

Also associated with

Rating

Method and compositions for solubilization and stabilization of does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method and compositions for solubilization and stabilization of , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method and compositions for solubilization and stabilization of will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-820515