Method and compositions for reducing the intraocular pressure of

Details Method and compositions for reducing the intraocular pressure of Method and compositions for reducing the intraocular pressure of

1985-12-20

1987-04-14

Siegel, Alan

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514357, 514399, 514415, 514427, 514471, 514521, 514523, 549 75, A61K 3138, A61K 3140, A61K 3134, C07D33312

Patent

active

046579257

ABSTRACT:
This invention provides a method for reducing the intraocular pressure in mammals which comprises administering an effective amount of a compound selected from the group consisting of compounds represented by the general formula: ##STR1## where R.sub.2, R.sub.3 and R.sub.4 are each selected from the group consisting of H, and OA; A is H or ##STR2## R.sub.5 is selected from the group consisting of alkyl and aromatic residues; n is 2 or 3; and R.sub.1 is selected from the group consisting of 3-hydroxyphenyl, 4-hydroxyphenyl, 3-pyridyl, 4-pyridyl, ##STR3## where X is S, O or NH, with the proviso that at least one of R.sub.2, R.sub.3 and R.sub.4 is H, that at least one of R.sub.2, R.sub.3 and R.sub.4 is not H and that R.sub.2 and R.sub.4 are not both OA; and pharmaceutically-acceptable salts thereof. This invention further provides compositions useful in such method of reducing the intraocular pressure in mammals.

REFERENCES:
patent: 3930022 (1975-12-01), Hauck et al.
patent: 4076843 (1978-02-01), Hauck et al.
patent: 4267373 (1981-05-01), Hauck et al.
patent: 4314082 (1982-02-01), Stout
patent: 4410519 (1983-10-01), Seiler et al.
patent: 4564628 (1986-01-01), Horn
McDermed et al., Journal of Medicinal Chemistry, 1975, vol. 18, No. 4, pp. 362-367.
Hacksell et al., Journal of Medicinal Chemistry, vol. 22, No. 12 at pp. 1469-1475.
Beaulieu et al., European Journal of Pharmacology, 105 (1984) at pp. 15-21.

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